Influence of vitamin C supplementation on the oxidative status of rat liver

Rats have the ability to synthesize vitamin C in the liver. In the present work, we tested whether its additional intake improves antioxidative protection of the tissue. Thus, we studied the liver oxidative status in rats given two supplements of ascorbic acid over a four-week period of time. Our re...

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Bibliographic Details
Published in:Archives of biological sciences 2008, Vol.60 (2), p.169-173
Main Authors: Djurasevic, S.F, Djordjevic, J, Drenca, T, Jasnic, N, Cvijic, G., University of Belgrade, Belgrade (Serbia). Faculty of Biology, Institute of Physiology and Biochemistry
Format: Article
Language:English
Subjects:
ACIDE ASCORBIQUE
ACIDO ASCORBICO
ANTIOXIDANTES
ANTIOXIDANTS
antioxidative protection
ANTIOXYDANT
ASCORBIC ACID
DIAGNOSIS
DIAGNOSTIC
DIAGNOSTICO
FOIE
HIGADO
http://www.fao.org/aos/agrovoc#c_2238
http://www.fao.org/aos/agrovoc#c_4395
http://www.fao.org/aos/agrovoc#c_511
http://www.fao.org/aos/agrovoc#c_6464
http://www.fao.org/aos/agrovoc#c_661
LIVER
RAT
RATA
RATS
Vitamin C
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Summary:Rats have the ability to synthesize vitamin C in the liver. In the present work, we tested whether its additional intake improves antioxidative protection of the tissue. Thus, we studied the liver oxidative status in rats given two supplements of ascorbic acid over a four-week period of time. Our results confirmed that the additional intake of ascorbate improves the liver antioxidative defense in a dose-dependent manner. The explanation for the disproportion between the ratio of employed doses of vitamin C and their effects on the studied parameters probably lies in the mechanism of tissue accumulation of ascorbate and balance of its alimentary and endogenous availability.
ISSN:0354-4664
1821-4339
DOI:10.2298/ABS0802169D