Viruses Causing Aseptic Meningitis: A Tertiary Medical Center Experience With a Multiplex PCR Assay

Central nervous system (CNS) infection is associated with high rates of morbidity and mortality, and despite advancements in molecular testing, aseptic meningitis remains challenging to diagnose. Aseptic meningitis cases are often underreported worldwide, which impacts the quality of patient care. T...

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Bibliographic Details
Published in:Frontiers in neurology 2020-12, Vol.11, p.602267-602267
Main Authors: Aldriweesh, Mohammed A, Shafaay, Edi A, Alwatban, Saud M, Alkethami, Obeid M, Aljuraisi, Faisal N, Bosaeed, Mohammad, Alharbi, Naif Khalaf
Format: Article
Language:English
Subjects:
CNS infection
diagnostic PCR
enterovirus
Filmarray ME panel
herpesvirus
Neurology
viral meningitis
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Summary:Central nervous system (CNS) infection is associated with high rates of morbidity and mortality, and despite advancements in molecular testing, aseptic meningitis remains challenging to diagnose. Aseptic meningitis cases are often underreported worldwide, which impacts the quality of patient care. Therefore, we aimed to assess the results of BioFire® FilmArray® meningitis/encephalitis (ME) PCR panel, clinical characteristics, and etiologies of aseptic meningitis patients. From January 2018 to January 2020, all pediatric and adult patients in a large tertiary medical center who underwent lumbar puncture and cerebrospinal fluid (CSF) testing by a ME multiplex PCR panel and who fit the aseptic meningitis definition were retrospectively reviewed. Data were reviewed from 1,607 patients; 240 met the inclusion criteria (54.6% males; 68.8%
ISSN:1664-2295
1664-2295
DOI:10.3389/fneur.2020.602267