The Role of Gamma-Delta T Cells in Diseases of the Central Nervous System

Gamma-delta (γδ) T cells are a subset of T cells that promote the inflammatory responses of lymphoid and myeloid lineages, and are especially vital to the initial inflammatory and immune responses. Given the capability to connect crux inflammations of adaptive and innate immunity, γδ T cells are res...

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Bibliographic Details
Published in:Frontiers in immunology 2020-10, Vol.11, p.580304-580304
Main Authors: Wo, Jin, Zhang, Feng, Li, Zhizhong, Sun, Chenghong, Zhang, Wencai, Sun, Guodong
Format: Article
Language:English
Subjects:
central nervous system
cytokines
IL-17
Immunology
inflammation
Th17 cell
γδ T cell
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Summary:Gamma-delta (γδ) T cells are a subset of T cells that promote the inflammatory responses of lymphoid and myeloid lineages, and are especially vital to the initial inflammatory and immune responses. Given the capability to connect crux inflammations of adaptive and innate immunity, γδ T cells are responsive to multiple molecular cues and can acquire the capacity to induce various cytokines, such as GM-CSF, IL-4, IL-17, IL-21, IL-22, and IFN-γ. Nevertheless, the exact mechanisms responsible for γδ T cell proinflammatory functions remain poorly understood, particularly in the context of the central nervous system (CNS) diseases. CNS disease, usually leading to irreversible cognitive and physical disability, is becoming a worldwide public health problem. Here, we offer a review of the neuro-inflammatory and immune functions of γδ T cells, intending to understand their roles in CNS diseases, which may be crucial for the development of novel clinical applications.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2020.580304