Cardiac magnetic resonance imaging-derived pathophysiology and prognosis of diabetes mellitus with acute myocardial infarction after revascularization: a prospective cohort study

• Published in: Annals of medicine (Helsinki) 2024-12, Vol.56 (1), p.2399751
• Main Authors: Li, Miaonan, Wang, Jun, Ding, Siyu, Ding, Bin, Oketunbi, Temilola J, Song, Xilong, Li, Yao, Niu, Qilin, Shi, Xiaojun, Gao, Dasheng, Hu, Sigan, Jin, Guoxi, Wang, Hongju
• Format: Article
• Language: English
• Subjects: acute myocardial infarction; Aged; cardiac magnetic resonance imaging; Cardiology & Cardiovascular Disorders; Diabetes mellitus; Diabetes Mellitus - epidemiology; Diabetes Mellitus - physiopathology; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonance Imaging, Cine - methods; major adverse cardiac and cerebrovascular events; Male; Middle Aged; Myocardial Infarction - diagnostic imaging; Myocardial Infarction - physiopathology; Myocardial Revascularization - statistics & numerical data; Prognosis; Prospective Studies; Risk Factors
• ISSN: 0785-3890; 1365-2060; 1365-2060
• DOI: 10.1080/07853890.2024.2399751

Little is known about the underlying factors contributing to unfavourable clinical outcomes in patients with diabetes mellitus (DM) complicated by new-onset acute myocardial infarction (AMI). The aim of this study was to investigate the impact of DM on the pathophysiologic features and prognosis of patients with new-onset AMI following successful revascularization by utilizing cardiac magnetic resonance (CMR). Consecutive patients diagnosed with new-onset AMI between June 2022 and January 2024 were included. All patients underwent culprit vessel revascularization upon admission and CMR imaging 3-7 days later. The primary clinical endpoint of this study was the occurrence of major adverse cardiac and cerebrovascular events (MACCEs), for which the average follow-up was 10 months. A total of 72 patients were divided into a DM group (  = 23) and a non-DM group (  = 49). Multivariate logistic regression analysis revealed that DM was an independent risk factor for the occurrence of microvascular obstruction. Multivariate linear regression analysis found that DM was the influencing factor of global radial strain (B = -4.107, t = -2.328,  = 0.023), while fasting blood glucose influenced infarct segment myocardial radial strain (B = -0.622, t = -2.032,  = 0.046). DM independently contributed to the risk of MACCEs following successful revascularization in patients with AMI (