Comparison of the Efficacy and Safety of Dexmedetomidine Administered in Two Different Modes Under Procedural Sedation and Analgesia in Plastic Surgery

Dexmedetomidine (DEX), a highly selective α2-adrenergic receptor agonist, is now widely used in procedural sedation and analgesia. This study was designed to observe and compare the efficacy and safety of DEX administered in two different modes. In total, 100 patients were randomly divided into two...

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Bibliographic Details
Published in:Frontiers in surgery 2022-05, Vol.9, p.836398-836398
Main Authors: Xia, Weipeng, Wang, Shanshan, Wei, Lingxin, Deng, Xiaoming, Yang, Dong, Sui, Jinghu, Liu, Juhui
Format: Article
Language:English
Subjects:
dexmedetomidine
hemodynamics
loading dose
procedural sedation and analgesia
respiration
Surgery
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Summary:Dexmedetomidine (DEX), a highly selective α2-adrenergic receptor agonist, is now widely used in procedural sedation and analgesia. This study was designed to observe and compare the efficacy and safety of DEX administered in two different modes. In total, 100 patients were randomly divided into two groups to receive intravenous DEX 1 µg/kg over 15 min followed by 0.4-0.7 µg/kg/h infusion or DEX 1 µg/kg over 30 min followed by 0.4-0.7 µg/kg/h infusion. Heart rate (HR), mean arterial pressure (MAP), respiratory rate (RR), bispectral index (BIS), Ramsay Sedation Scores (RSS scores), the lowest respiratory rates (LRR), incidences of respiratory adverse events and frequencies of body movements were recorded. Recovery time, recall of intraoperative events, pain scores in PACU and satisfaction of patients and surgeons were assessed. The BIS at time points from 5 min after anesthesia to the end of surgery in the intervention group were significantly higher (  
ISSN:2296-875X
2296-875X
DOI:10.3389/fsurg.2022.836398