A meta-analysis of the therapeutic effect of intranasal salmon calcitonin on osteoporosis

To evaluate the efficacy and safety of intranasal salmon calcitonin in the treatment of osteoporosis. Eight Chinese and English databases were searched by electronic search (from the establishment of the database to October 2019). The literature was screened according to the inclusion criteria and e...

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Published in:European journal of medical research 2021-12, Vol.26 (1), p.140-140, Article 140
Main Authors: Li, Ning, Gong, Yi Chen, Chen, Jianer
Format: Article
Language:English
Subjects:
Administration, Intranasal
Analysis
Bias
Bone Density Conservation Agents - administration & dosage
Calcitonin - administration & dosage
Care and treatment
Clinical trials
Creatinine
Database searching
Drugs
Fractures
Health aspects
Humans
Internet/Web search services
Intervention
Intranasal salmon calcitonin
Lumbar Vertebrae
Meta-analysis
Online searching
Osteoporosis
Osteoporosis, Postmenopausal - prevention & control
Phosphatase
Phosphatases
Review
Risk assessment
Software reviews
Vitamin D
Womens health
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description To evaluate the efficacy and safety of intranasal salmon calcitonin in the treatment of osteoporosis. Eight Chinese and English databases were searched by electronic search (from the establishment of the database to October 2019). The literature was screened according to the inclusion criteria and exclusion criteria, the quality was evaluated according to Cochrane software, and the Review Manager 5.2 software was used for statistical analysis. A total of 374 documents were retrieved and 12 (12 original studies) were included after the screening, with a total sample capacity of 1068 cases. Meta-analysis showed that the intranasal salmon calcitonin had obvious advantages in reducing blood calcium, improving the ratio of serum creatinine and alkaline phosphatase. In addition, the intranasal salmon calcitonin had no obvious advantages in other indicators. It cannot be illustrated that the combination of intranasal salmon calcitonin and other conventional drugs is more effective than the simple use of conventional drugs. The intranasal salmon calcitonin is superior to conventional drugs in reducing blood calcium, increasing creatinine ratio, and alkaline phosphatase, but its advantages in other indicators such as improving the bone mineral density (BMD) of lumbar vertebrae and hip have not been confirmed, and it is not clear that the combination of intranasal salmon calcitonin and other conventional drugs is better than the simple conventional drugs.
doi_str_mv 10.1186/s40001-021-00610-x
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identifier ISSN: 2047-783X
ispartof European journal of medical research, 2021-12, Vol.26 (1), p.140-140, Article 140
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subjects Administration, Intranasal
Analysis
Bias
Bone Density Conservation Agents - administration & dosage
Calcitonin - administration & dosage
Care and treatment
Clinical trials
Creatinine
Database searching
Drugs
Fractures
Health aspects
Humans
Internet/Web search services
Intervention
Intranasal salmon calcitonin
Lumbar Vertebrae
Meta-analysis
Online searching
Osteoporosis
Osteoporosis, Postmenopausal - prevention & control
Phosphatase
Phosphatases
Review
Risk assessment
Software reviews
Vitamin D
Womens health
title A meta-analysis of the therapeutic effect of intranasal salmon calcitonin on osteoporosis
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