Strontium Ranelate Elevates Expression of Heme Oxygenase-1 and Decreases Alveolar Bone Loss in Rats

The purpose of this study was to determine the effects of strontium ranelate on ligature-induced periodontitis in rats and assess the putative involvement of heme oxygenase-1 (HO-1) pathway in these effects. Male Wistar rats underwent nylon ligature placement around maxillary molars and were treated...

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Bibliographic Details
Published in:Journal of oral & maxillofacial research 2018-12, Vol.9 (4), p.e4-e4
Main Authors: Souza, Ricardo Basto, Gomes, Francisco Isaac Fernandes, Pereira, Karuza Maria Alves, Dutra, Paula Goes Pinheiro, da Cunha, Rodrigo Maranguape Silva, Chaves, Hellíada Vasconcelos, Bezerra, Mirna Marques
Format: Article
Language:English
Subjects:
bone resorption
diphosphonates
heme oxygenase
Original Paper
periodontitis
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Summary:The purpose of this study was to determine the effects of strontium ranelate on ligature-induced periodontitis in rats and assess the putative involvement of heme oxygenase-1 (HO-1) pathway in these effects. Male Wistar rats underwent nylon ligature placement around maxillary molars and were treated (v.o.) with strontium ranelate (20 or 100 mg/kg) for 7 days. After that, rats were euthanized and histomorphometric/histopathological analyses and RT-PCR for HO-1 expression were performed. Strontium ranelate (20 or 100 mg/kg) prevented bone resorption by 28% and 38%, respectively. Strontium ranelate treatment (100 mg/kg) up-regulated (P < 0.05) heme oxygenase-1 mRNA levels in the gingival tissues in comparison to control groups. Strontium ranelate prevented periodontal bone loss in experimental periodontitis in rats while heme oxygenase-1 mRNA levels increased after treatment.
ISSN:2029-283X
2029-283X
DOI:10.5037/jomr.2018.9404