Comparison of Surrogate Markers of the Type I Interferon Response and Their Ability to Mirror Disease Activity in Systemic Lupus Erythematosus

ObjectivesType I interferons (IFNs) are central and reflective of disease activity in systemic lupus erythematosus (SLE). However, IFN-α levels are notoriously difficult to measure and the type I IFN gene signature (IGS) is not yet available in clinical routine. This study evaluates galectin-9 and a...

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Bibliographic Details
Published in:Frontiers in immunology 2021-06, Vol.12, p.688753-688753
Main Authors: Enocsson, Helena, Wetterö, Jonas, Eloranta, Maija-Leena, Gullstrand, Birgitta, Svanberg, Cecilia, Larsson, Marie, Bengtsson, Anders A., Rönnblom, Lars, Sjöwall, Christopher
Format: Article
Language:English
Subjects:
biomarker
chemokine
Clinical Medicine
disease activity
galectin
Immunology
interferon
Klinisk medicin
lupus
Medical and Health Sciences
Medicin och hälsovetenskap
Reumatologi och inflammation
Rheumatology and Autoimmunity
SLE
TNF
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Summary:ObjectivesType I interferons (IFNs) are central and reflective of disease activity in systemic lupus erythematosus (SLE). However, IFN-α levels are notoriously difficult to measure and the type I IFN gene signature (IGS) is not yet available in clinical routine. This study evaluates galectin-9 and an array of chemokines/cytokines in their potential as surrogate markers of type I IFN and/or SLE disease activity. MethodsHealthy controls and well-characterized Swedish SLE patients from two cross-sectional cohorts (n=181; n=59) were included, and a subgroup (n=21) was longitudinally followed. Chemokine/cytokine responses in immune complex triggered IFN-α activity was studied in healthy donor peripheral blood mononuclear cells (PBMC). Levels of chemokines/cytokines and galectin-9 were measured by immunoassays. Gene expression was quantified by qPCR. ResultsThe IGS was significantly (p
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2021.688753