The effects of antithrombotic therapy on head trauma and its management

• Published in: Scientific reports 2021-10, Vol.11 (1), p.20459-20459, Article 20459
• Main Authors: Koiso, Takao, Goto, Masayuki, Terakado, Toshitsugu, Komatsu, Yoji, Matsumaru, Yuji, Ishikawa, Eichi
• Format: Article
• Language: English
• Subjects: 631/154/1438; 692/699/375/534; 692/699/578; Aged; Aged, 80 and over; Anticoagulants; Anticoagulants - adverse effects; Craniocerebral Trauma - complications; Craniocerebral Trauma - diagnostic imaging; Craniocerebral Trauma - mortality; Demography; Enlargement; Female; Fibrinolytic Agents - adverse effects; Head injuries; Hematoma; Hemorrhage; Humanities and Social Sciences; Humans; Intracranial Hemorrhage, Traumatic - chemically induced; Intracranial Hemorrhage, Traumatic - epidemiology; Japan; Male; Middle Aged; multidisciplinary; Multivariate analysis; Patients; Platelet Aggregation Inhibitors - adverse effects; Retrospective Studies; Risk Factors; Science; Science (multidisciplinary); Tomography, X-Ray Computed; Trauma; Vitamin K; Vitamin K - antagonists & inhibitors
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-021-00091-2

The number of patients with traumatic intracranial hemorrhage (tICH) that are taking antithrombotics (ATs), antiplatelets (APs) and/or anticoagulants (ACs), has increased, but the influence of it for outcome remains unclear. This study aimed to evaluate an influence of AT for tICH. We retrospectively reviewed all patients with tICH treated between 2012 and 2019, and analyzed demographics, neurological status, clinical course, radiological findings, and outcome data. A total of 393 patients with tICH were included; 117 were on AT therapy (group A) and 276 were not (group B). Fifty-one (43.6%) and 159 (57.6%) patients in groups A and B, respectively, exhibited mRS of 0–2 at discharge (p = 0.0113). Mortality at 30 days was significantly higher in group A than in group B (25.6% vs 16.3%, p = 0.0356). Multivariate analysis revealed that higher age (OR 32.7, p