Isothiocyanate-Functionalized Mesoporous Silica Nanoparticles as Building Blocks for the Design of Nanovehicles with Optimized Drug Release Profile

A straightforward methodology for the synthesis of isothiocyanate-functionalized mesoporous silica nanoparticles (MSNs) by exposure of aminated MSNs to 1,1'-thiocarbonyldi-2(1 )-pyridone is reported. These nanoparticles are chemically stable, water tolerant, and readily react with primary amine...

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Bibliographic Details
Published in:Nanomaterials (Basel, Switzerland) Switzerland), 2019-08, Vol.9 (9), p.1219
Main Authors: Martínez-Edo, Gabriel, Llinàs, Maria C, Borrós, Salvador, Sánchez-García, David
Format: Article
Language:English
Subjects:
Amines
Design optimization
drug delivery
Drug delivery systems
Drug development
Ethanol
Isothiocyanate
mesoporous silica nanoparticles
Nanoparticles
Organic chemistry
Physical properties
regioselective functionalization
Silica
Silicon dioxide
Surfactants
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Summary:A straightforward methodology for the synthesis of isothiocyanate-functionalized mesoporous silica nanoparticles (MSNs) by exposure of aminated MSNs to 1,1'-thiocarbonyldi-2(1 )-pyridone is reported. These nanoparticles are chemically stable, water tolerant, and readily react with primary amines without the formation of any by-product. This feature allows the easy modification of the surface of the nanoparticles for tuning their physical properties and the introduction of gatekeepers on the pore outlets. As a proof-of-concept, amino-isothiocyanate-functionalized MSNs have been used for the design of a nanocontainer able to release the drug Ataluren. The release profile of the drug can be easily fine-tuned with the careful choice of the capping amine.
ISSN:2079-4991
2079-4991
DOI:10.3390/nano9091219