Therapies Targeted at Non-Coding RNAs in Prevention and Limitation of Myocardial Infarction and Subsequent Cardiac Remodeling—Current Experience and Perspectives

Myocardial infarction is one of the major causes of mortality worldwide and is a main cause of heart failure. This disease appears as a final point of atherosclerotic plaque progression, destabilization, and rupture. As a consequence of cardiomyocytes death during the infarction, the heart undergoes...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-05, Vol.22 (11), p.5718
Main Authors: Kowara, Michal, Borodzicz-Jazdzyk, Sonia, Rybak, Karolina, Kubik, Maciej, Cudnoch-Jedrzejewska, Agnieszka
Format: Article
Language:English
Subjects:
atherosclerotic plaque
circRNA
lncRNA
miRNA
myocardial infarction
ncRNA
Review
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Summary:Myocardial infarction is one of the major causes of mortality worldwide and is a main cause of heart failure. This disease appears as a final point of atherosclerotic plaque progression, destabilization, and rupture. As a consequence of cardiomyocytes death during the infarction, the heart undergoes unfavorable cardiac remodeling, which results in its failure. Therefore, therapies aimed to limit the processes of atherosclerotic plaque progression, cardiac damage during the infarction, and subsequent remodeling are urgently warranted. A hopeful therapeutic option for the future medicine is targeting and regulating non-coding RNA (ncRNA), like microRNA, circular RNA (circRNA), or long non-coding RNA (lncRNA). In this review, the approaches targeted at ncRNAs participating in the aforementioned pathophysiological processes involved in myocardial infarction and their outcomes in preclinical studies have been concisely presented.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22115718