Blood Phytosterol Concentration and Genetic Variant Associations in a Sample Population

The main objective of this study was to determine plasma levels of PS and to study SNVs rs41360247, rs4245791, rs4148217, and rs11887534 of and the r657152 SNV at the ABO blood group locus in a sample of a population treated at our hospital, and to determine whether these SNVs are related to plasma...

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Published in:Nutrients 2024-04, Vol.16 (7), p.1067
Main Authors: Garrido-Sanchez, Leticia, Leiva-Badosa, Elisabet, Llop-Talaveron, Josep, Pintó-Sala, Xavier, Lozano-Andreu, Toni, Corbella-Inglés, Emili, Alia-Ramos, Pedro, Arias-Barquet, Lluis, Ramon-Torrel, Josep Maria, Badía-Tahull, Maria B
Format: Article
Language:English
Subjects:
ABCG5/8
ABO Blood-Group System
Adult
Alleles
Antilipemic agents
Blood groups
campesterol
Cardiovascular disease
Cholesterol
Chronic illnesses
Creatinine
Ethylenediaminetetraacetic acid
Generalized linear models
Genetic research
Genetic testing
Humans
Lanosterol
Medical research
Medicine, Experimental
Nutrition research
Nuts
Observational studies
Parenteral nutrition
Phytosterols
Plasma
Population
Questionnaires
sitosterol
SNVs
Statistical analysis
Sterols
Stigmasterol
Triglycerides
Variables
Vegetarianism
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Summary:The main objective of this study was to determine plasma levels of PS and to study SNVs rs41360247, rs4245791, rs4148217, and rs11887534 of and the r657152 SNV at the ABO blood group locus in a sample of a population treated at our hospital, and to determine whether these SNVs are related to plasma PS concentrations. The secondary objective was to establish the variables associated with plasma PS concentrations in adults. Participants completed a dietary habit questionnaire and a blood sample was collected to obtain the following variables: campesterol, sitosterol, sitostanol, lanosterol, stigmasterol, biochemical parameters, and the SNVs. In addition, biometric and demographic variables were also recorded. In the generalized linear model, cholesterol and age were positively associated with total PS levels, while BMI was negatively related. For rs4245791, homozygous T allele individuals showed a significantly lower campesterol concentration compared with C homozygotes, and the GG alleles of rs657152 had the lowest levels of campesterol compared with the other alleles of the SNV. Conclusions: The screening of certain SNVs could help prevent the increase in plasma PS and maybe PNALD in some patients. However, further studies on the determinants of plasma phytosterol concentrations are needed.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu16071067