LIN28 Family in Testis: Control of Cell Renewal, Maturation, Fertility and Aging

Male reproductive development starts early in the embryogenesis with somatic and germ cell differentiation in the testis. The LIN28 family of RNA-binding proteins promoting pluripotency has two members—LIN28A and LIN28B. Their function in the testis has been investigated but many questions about the...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-06, Vol.23 (13), p.7245
Main Authors: Krsnik, Dajana, Marić, Tihana, Bulić-Jakuš, Floriana, Sinčić, Nino, Bojanac, Ana Katušić
Format: Article
Language:English
Subjects:
Aging
cancer
Cell differentiation
Cell proliferation
Chemical compounds
Differentiation (biology)
Dwarfism
Embryogenesis
Fertility
Fetuses
Fibroblasts
Gene expression
Genetic engineering
Germ cells
Hypogonadism
Hypothalamus
infertility
Klinefelter's syndrome
Leydig cells
LIN28A
LIN28B
Mammals
Maturation
Metabolism
MicroRNAs
Ovaries
Pharmacology
Pituitary gland
Placenta
Pluripotency
Pregnancy
Proteins
Puberty
Review
RNA-binding protein
Spermatids
Spermatogonia
Stem cells
Testes
Testicular cancer
testis
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Summary:Male reproductive development starts early in the embryogenesis with somatic and germ cell differentiation in the testis. The LIN28 family of RNA-binding proteins promoting pluripotency has two members—LIN28A and LIN28B. Their function in the testis has been investigated but many questions about their exact role based on the expression patterns remain unclear. LIN28 expression is detected in the gonocytes and the migrating, mitotically active germ cells of the fetal testis. Postnatal expression of LIN28 A and B showed differential expression, with LIN28A expressed in the undifferentiated spermatogonia and LIN28B in the elongating spermatids and Leydig cells. LIN28 interferes with many signaling pathways, leading to cell proliferation, and it is involved in important testicular physiological processes, such as cell renewal, maturation, fertility, and aging. In addition, aberrant LIN28 expression is associated with testicular cancer and testicular disorders, such as hypogonadotropic hypogonadism and Klinefelter’s syndrome. This comprehensive review encompasses current knowledge of the function of LIN28 paralogs in testis and other tissues and cells because many studies suggest LIN28AB as a promising target for developing novel therapeutic agents.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23137245