Ginsenosides and Polysaccharides from Ginseng Co-Fermented with Multi-Enzyme-Coupling Probiotics Improve In Vivo Immunomodulatory Effects

The active components of ginseng, such as ginsenosides and polysaccharides, have high therapeutic value in treating cancer, decreasing obesity, and enhancing immunity. However, simple primary ginseng treatment cannot maximize this medicinal potential. Therefore, in this study, was co-fermented with...

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Bibliographic Details
Published in:Nutrients 2023-05, Vol.15 (11), p.2434
Main Authors: Bai, Shaowei, Zhang, Guangyun, Han, Yaqin, Ma, Jianwei, Bai, Bing, Gao, Jingjie, Zhang, Zuoming
Format: Article
Language:English
Subjects:
Cyclophosphamide
enzyme
Enzymes
Fermentation
Ginseng
Ginsenosides
Health aspects
Homeostasis
Immune response
Immune system
Immunomodulation
Immunomodulators
Immunosuppression
Immunotherapy
intestinal flora
Intestinal microflora
Laboratory animals
Microbiota (Symbiotic organisms)
Panax ginseng
Polysaccharides
Probiotics
Proteins
Saccharides
Sulfuric acid
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Summary:The active components of ginseng, such as ginsenosides and polysaccharides, have high therapeutic value in treating cancer, decreasing obesity, and enhancing immunity. However, simple primary ginseng treatment cannot maximize this medicinal potential. Therefore, in this study, was co-fermented with multi-enzyme-coupling probiotics to obtain a fermentation broth with higher levels of ginsenosides, polysaccharides, and probiotics. When compared to other treatment methods for cyclophosphamide-induced immunosuppression in mice, the results reveal that the fermentation broth treated with multi-enzyme-coupling probiotics could significantly improve the immune function of immunosuppressive mice and restore intestinal flora stability. Overall, this processing method will provide a novel strategy for promoting the application of ginseng and the relief of immunosuppression.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu15112434