“Every Cloud Has a Silver Lining”: How Three Rare Diseases Defend Themselves from COVID-19 and What We Have Learnt from It

The process of SARS-CoV-2 infection, responsible for the COVID-19 pandemic, is carried out through different steps, with the interaction between ACE2 and Spike protein (S) being crucial. Besides of that, the acidic environment of endosomes seems to play a relevant role in the virus uptake into cells...

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Bibliographic Details
Published in:Clinics and practice 2024-04, Vol.14 (2), p.614-618
Main Authors: Cacciapuoti, Martina, Caputo, Ilaria, Stefanelli, Lucia Federica, Davis, Paul A., Nalesso, Federico, Calò, Lorenzo A.
Format: Article
Language:English
Subjects:
ACE2
Alkalosis
Asymptomatic
Bartter’s syndrome
Cathepsin-L
COVID-19
COVID-19 vaccines
Diabetes
Disease
Fabry disease
Gitelman’s syndrome
Hypertension
Immunization
Infections
Kinases
Metabolism
Proteins
Severe acute respiratory syndrome coronavirus 2
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Summary:The process of SARS-CoV-2 infection, responsible for the COVID-19 pandemic, is carried out through different steps, with the interaction between ACE2 and Spike protein (S) being crucial. Besides of that, the acidic environment of endosomes seems to play a relevant role in the virus uptake into cells and its intracellular replication. Patients affected by two rare genetic tubulopathies, Gitelman’s and Bartter’s Syndromes, and a rare genetic metabolic disease, Fabry Disease, have shown intrinsic protection from SARS-CoV-2 infection and COVID-19 on account of specific intrinsic features that interfere with the virus uptake into cells and its intracellular replication, which will be reported and discussed in this paper, providing interesting insights for present and future research.
ISSN:2039-7283
2039-7275
2039-7283
DOI:10.3390/clinpract14020048