Mitochondrial Mechanisms of Apoptosis and Necroptosis in Liver Diseases

In addition to playing a pivotal role in cellular energetics and biosynthesis, mitochondrial components are key operators in the regulation of cell death. In addition to apoptosis, necrosis is a highly relevant form of programmed liver cell death. Differential activation of specific forms of program...

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Bibliographic Details
Published in:Analytical cellular pathology (Amsterdam) 2021, Vol.2021, p.8900122-9
Main Authors: Chu, Qingfei, Gu, Xinyu, Zheng, Qiuxian, Wang, Jing, Zhu, Haihong
Format: Article
Language:English
Subjects:
Animals
Apoptosis - physiology
Humans
Liver Diseases - pathology
Mitochondria - physiology
Necroptosis - physiology
Review
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Summary:In addition to playing a pivotal role in cellular energetics and biosynthesis, mitochondrial components are key operators in the regulation of cell death. In addition to apoptosis, necrosis is a highly relevant form of programmed liver cell death. Differential activation of specific forms of programmed cell death may not only affect the outcome of liver disease but may also provide new opportunities for therapeutic intervention. This review describes the role of mitochondria in cell death and the mechanism that leads to chronic liver hepatitis and liver cirrhosis. We focus on mitochondrial-driven apoptosis and current knowledge of necroptosis and discuss therapeutic strategies for targeting mitochondrial-mediated cell death in liver diseases.
ISSN:2210-7177
2210-7185
DOI:10.1155/2021/8900122