Hemolysis and Inflammatory Response to Extracorporeal Circulation during On-Pump CABG: Comparison between Roller and Centrifugal Pump Systems

To compare the perioperative incidence rates of hemolysis and inflammatory response in patients undergoing coronary artery bypass grafting with the two main types of cardiopulmonary bypass, centrifugal and roller pumps, and establish correlations among hemolytic and inflammatory changes. This was a...

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Bibliographic Details
Published in:Revista brasileira de cirurgia cardiovascular 2018-01, Vol.33 (1), p.64-71
Main Authors: Passaroni, Andréia Cristina, Felicio, Marcello Laneza, Campos, Nelson Leonardo Kerdahi Leite de, Silva, Marcos Augusto de Moraes, Yoshida, Winston Bonida
Format: Article
Language:English
Subjects:
Adult
Aged
Anesthesia
Automation
Biomarkers - blood
Body temperature
CARDIAC & CARDIOVASCULAR SYSTEMS
Cardiology
Cardiopulmonary Bypass
Cardiopulmonary Bypass - adverse effects
Cardiopulmonary Bypass - methods
Coronary vessels
Extracorporeal Circulation - adverse effects
Extracorporeal Circulation - methods
Female
Heart surgery
Hemolysis
Humans
Incidence
Independent sample
Inflammation
Inflammation - etiology
Male
Middle Aged
Original
Perioperative Period
Prospective Studies
SURGERY
Systematic review
Trauma
Tumor necrosis factor-TNF
Variance analysis
Veins & arteries
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Summary:To compare the perioperative incidence rates of hemolysis and inflammatory response in patients undergoing coronary artery bypass grafting with the two main types of cardiopulmonary bypass, centrifugal and roller pumps, and establish correlations among hemolytic and inflammatory changes. This was a prospective, randomized trial of 60 patients assigned to either roller pump (G1, n=30) or centrifugal pump (G2, n=30) bypass. Markers of hemolysis (serum haptoglobin, lactate dehydrogenase [LDH]) and inflammation (interleukin [IL]1ß, IL-6, and TNF-α) were measured and analyzed. There was no significant between-group difference in the variables of interest. In G1, there was a positive association with IL-6 and TNF-α (P
ISSN:1678-9741
0102-7638
1678-9741
DOI:10.21470/1678-9741-2017-0125