aaquetzalli is required for epithelial cell polarity and neural tissue formation in Drosophila

Morphogenetic movements during embryogenesis require dynamic changes in epithelial cell polarity and cytoskeletal reorganization. Such changes involve, among others, rearrangements of cell-cell contacts and protein traffic. In , neuroblast delamination during early neurogenesis is a well-characteriz...

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Bibliographic Details
Published in:PeerJ (San Francisco, CA) CA), 2018-06, Vol.6, p.e5042-e5042, Article e5042
Main Authors: Mendoza-Ortíz, Miguel A, Murillo-Maldonado, Juan M, Riesgo-Escovar, Juan R
Format: Article
Language:English
Subjects:
Cadherins
Cell division
Cell polarity
Cytoskeleton
Developmental Biology
Drosophila
Drosophila melanogaster
Ectoderm
Embryogenesis
Embryonic developent
Epithelia
Epithelial cells
Genes
Genetics
Homology
Insects
Life cycles
Localization
Membrane proteins
Nervous system
Neurobiology
Neurogenesis
Neurosciences
Neurulation
Notch protein
Polarity
Proline
Protein transport
Proteins
Signal transduction
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Summary:Morphogenetic movements during embryogenesis require dynamic changes in epithelial cell polarity and cytoskeletal reorganization. Such changes involve, among others, rearrangements of cell-cell contacts and protein traffic. In , neuroblast delamination during early neurogenesis is a well-characterized process requiring a polarized neuroepithelium, regulated by the Notch signaling pathway. Maintenance of epithelial cell polarity ensues proper Notch pathway activation during neurogenesis. We characterize here ( ), a gene whose mutations affect cell polarity and nervous system specification. The locus encodes a protein that harbors a domain with significant homology to a proline-rich conserved domain of nuclear receptor co-activators. expression occurs at all stages of the fly life cycle, and is dynamic. mutants are lethal, showing a disruption of cell polarity during embryonic ventral neuroepithelium differentiation resulting in loss of epithelial integrity and mislocalization of membrane proteins (shown by mislocalization of Crumbs, DE-Cadherin, and Delta). As a consequence, mutant embryos with compromised apical-basal cell polarity develop spotty changes of neuronal and epithelial numbers of cells.
ISSN:2167-8359
2167-8359
DOI:10.7717/peerj.5042