Intermediate Filaments in Breast Cancer Progression, and Potential Biomarker for Cancer Therapy: A Narrative Review

Intermediate filaments are one of the three components of the cytoskeletons, along with actin and microtubules. The intermediate filaments consist of extensive variations of structurally related proteins with specific expression patterns in cell types. The expression pattern alteration of intermedia...

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Bibliographic Details
Published in:Breast cancer targets and therapy 2024-10, Vol.16, p.689-704
Main Authors: Shalannandia, Widad Aghnia, Chou, Yoan, Bashari, Muhammad Hasan, Khairani, Astrid Feinisa
Format: Article
Language:English
Subjects:
Antimitotic agents
Antineoplastic agents
Breast cancer
breast malignancy
Cancer
Care and treatment
cytokeratin
Development and progression
emt
Health aspects
intermediate filament
Keratin
Muscle proteins
nestin
Stem cells
vimentin
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Summary:Intermediate filaments are one of the three components of the cytoskeletons, along with actin and microtubules. The intermediate filaments consist of extensive variations of structurally related proteins with specific expression patterns in cell types. The expression pattern alteration of intermediate filaments is frequently correlated with cancer progression, specifically with the epithelial-to-mesenchymal transition process closely related to increasing cellular migration and invasion. This review will discuss the involvement of cytoplasmic intermediate filaments, specifically vimentin, nestin, and cytokeratin (CK5/CK6, CK7, CK8/CK18, CK17, CK19, CK20, CSK1), in breast cancer progression and as prognostic or diagnostic biomarkers. The potential for drug development targeting intermediate filaments in cancer will be reviewed.
ISSN:1179-1314
1179-1314
DOI:10.2147/BCTT.S489953