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The Role of Zinc in the Development of Vascular Dementia and Parkinson's Disease and the Potential of Carnosine as Their Therapeutic Agent
Synaptic zinc ions (Zn ) play an important role in the development of vascular dementia (VD) and Parkinson's disease (PD). In this article, we reviewed the current comprehension of the Zn -induced neurotoxicity that leads to the pathogenesis of these neuronal diseases. Zn -induced neurotoxicity...
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| Published in: | Biomedicines 2024-06, Vol.12 (6), p.1296 |
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| Main Authors: | , , , , |
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| container_issue | 6 |
| container_start_page | 1296 |
| container_title | Biomedicines |
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| creator | Mizuno, Dai Kawahara, Masahiro Konoha-Mizuno, Keiko Hama, Ryoji Ogawara, Terumasa |
| description | Synaptic zinc ions (Zn
) play an important role in the development of vascular dementia (VD) and Parkinson's disease (PD). In this article, we reviewed the current comprehension of the Zn
-induced neurotoxicity that leads to the pathogenesis of these neuronal diseases. Zn
-induced neurotoxicity was investigated by using immortalised hypothalamic neurons (GT1-7 cells). This cell line is useful for the development of a rapid and convenient screening system for investigating Zn
-induced neurotoxicity. GT1-7 cells were also used to search for substances that prevent Zn
-induced neurotoxicity. Among the tested substances was a protective substance in the extract of Japanese eel (
), and we determined its structure to be like carnosine (β-alanylhistidine). Carnosine may be a therapeutic drug for VD and PD. Furthermore, we reviewed the molecular mechanisms that involve the role of carnosine as an endogenous protector and its protective effect against Zn
-induced cytotoxicity and discussed the prospects for the future therapeutic applications of this dipeptide for neurodegenerative diseases and dementia. |
| doi_str_mv | 10.3390/biomedicines12061296 |
| format | article |
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) play an important role in the development of vascular dementia (VD) and Parkinson's disease (PD). In this article, we reviewed the current comprehension of the Zn
-induced neurotoxicity that leads to the pathogenesis of these neuronal diseases. Zn
-induced neurotoxicity was investigated by using immortalised hypothalamic neurons (GT1-7 cells). This cell line is useful for the development of a rapid and convenient screening system for investigating Zn
-induced neurotoxicity. GT1-7 cells were also used to search for substances that prevent Zn
-induced neurotoxicity. Among the tested substances was a protective substance in the extract of Japanese eel (
), and we determined its structure to be like carnosine (β-alanylhistidine). Carnosine may be a therapeutic drug for VD and PD. Furthermore, we reviewed the molecular mechanisms that involve the role of carnosine as an endogenous protector and its protective effect against Zn
-induced cytotoxicity and discussed the prospects for the future therapeutic applications of this dipeptide for neurodegenerative diseases and dementia.</description><identifier>ISSN: 2227-9059</identifier><identifier>EISSN: 2227-9059</identifier><identifier>DOI: 10.3390/biomedicines12061296</identifier><identifier>PMID: 38927502</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Amino acids ; Anguilla japonica ; Apoptosis ; Binswanger's disease ; Carnosine ; Cell death ; Cytotoxicity ; Dementia ; Dementia disorders ; Diet therapy ; Disease ; Diseases ; Dopamine ; endoplasmic reticulum stress ; Enzymes ; Ethylenediaminetetraacetic acid ; Genes ; Health aspects ; Homeostasis ; Hypothalamus ; Ischemia ; Japan ; Kinases ; Molecular modelling ; Movement disorders ; Neurodegenerative diseases ; Neurotoxicity ; Older people ; Oxidative stress ; Parkinson's disease ; Pathogenesis ; Physiological aspects ; Proteins ; Review ; Sexually transmitted diseases ; STD ; synapse ; Synaptogenesis ; Therapeutic applications ; Transcription factors ; Vascular dementia ; Zinc</subject><ispartof>Biomedicines, 2024-06, Vol.12 (6), p.1296</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 by the authors. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c449t-a0374a00057950b60ef3d85cfd431705d209d8e7a2c225f8e1c7e0a7b36677fb3</cites><orcidid>0000-0002-4301-829X ; 0000-0002-3334-4235</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/3072288310/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/3072288310?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38927502$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mizuno, Dai</creatorcontrib><creatorcontrib>Kawahara, Masahiro</creatorcontrib><creatorcontrib>Konoha-Mizuno, Keiko</creatorcontrib><creatorcontrib>Hama, Ryoji</creatorcontrib><creatorcontrib>Ogawara, Terumasa</creatorcontrib><title>The Role of Zinc in the Development of Vascular Dementia and Parkinson's Disease and the Potential of Carnosine as Their Therapeutic Agent</title><title>Biomedicines</title><addtitle>Biomedicines</addtitle><description>Synaptic zinc ions (Zn
) play an important role in the development of vascular dementia (VD) and Parkinson's disease (PD). In this article, we reviewed the current comprehension of the Zn
-induced neurotoxicity that leads to the pathogenesis of these neuronal diseases. Zn
-induced neurotoxicity was investigated by using immortalised hypothalamic neurons (GT1-7 cells). This cell line is useful for the development of a rapid and convenient screening system for investigating Zn
-induced neurotoxicity. GT1-7 cells were also used to search for substances that prevent Zn
-induced neurotoxicity. Among the tested substances was a protective substance in the extract of Japanese eel (
), and we determined its structure to be like carnosine (β-alanylhistidine). Carnosine may be a therapeutic drug for VD and PD. Furthermore, we reviewed the molecular mechanisms that involve the role of carnosine as an endogenous protector and its protective effect against Zn
-induced cytotoxicity and discussed the prospects for the future therapeutic applications of this dipeptide for neurodegenerative diseases and dementia.</description><subject>Amino acids</subject><subject>Anguilla japonica</subject><subject>Apoptosis</subject><subject>Binswanger's disease</subject><subject>Carnosine</subject><subject>Cell death</subject><subject>Cytotoxicity</subject><subject>Dementia</subject><subject>Dementia disorders</subject><subject>Diet therapy</subject><subject>Disease</subject><subject>Diseases</subject><subject>Dopamine</subject><subject>endoplasmic reticulum stress</subject><subject>Enzymes</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Genes</subject><subject>Health aspects</subject><subject>Homeostasis</subject><subject>Hypothalamus</subject><subject>Ischemia</subject><subject>Japan</subject><subject>Kinases</subject><subject>Molecular modelling</subject><subject>Movement disorders</subject><subject>Neurodegenerative diseases</subject><subject>Neurotoxicity</subject><subject>Older people</subject><subject>Oxidative stress</subject><subject>Parkinson's disease</subject><subject>Pathogenesis</subject><subject>Physiological aspects</subject><subject>Proteins</subject><subject>Review</subject><subject>Sexually transmitted diseases</subject><subject>STD</subject><subject>synapse</subject><subject>Synaptogenesis</subject><subject>Therapeutic applications</subject><subject>Transcription factors</subject><subject>Vascular dementia</subject><subject>Zinc</subject><issn>2227-9059</issn><issn>2227-9059</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptks1u1DAUhSMEolXpGyBkiQVspvgvcbxCoymFSpWoUGHBxnKcm6mHjD21k0q8Ak_dm5lSOqiJFEfH53z2tW9RvGb0RAhNPzQ-rqH1zgfIjNOKcV09Kw4552qmaamfP_o_KI5zXlF8NBM1ky-LA1FrrkrKD4s_V9dAvsUeSOzITx8c8YEMqJ3CLfRxs4YwTFM_bHZjbxPqk-QtsaEllzb98iHH8C6TU5_BZtjqE-AyDltjP8UXNoWYcbfEZoJL-jR9k93AOHhH5ku0vipedLbPcHw_HhXfzz5dLb7MLr5-Pl_ML2ZOSj3MLBVKWqymVLqkTUWhE21duq6VgilatpzqtgZlueO87GpgTgG1qhFVpVTXiKPifMdto12ZTfJrm36baL3ZCjEtjU24qx5MyyrRVC2XzpWSOtlw3jlEVyWo2kGFrI871mZs8EIclpFsvwfdnwn-2izjrWF4a6ymGgnv7wkp3oyQB7P22UHf2wBxzEZQxWsqKsXR-vY_6yqOKeBZbV28rgWj_1xLixX40EVc2E1QM1dacymFqNF18oQL3xbW3sUAnUd9LyB3AZdizgm6hyIZNVNPmqd6EmNvHh_QQ-hvB4o7GZHfRA</recordid><startdate>20240611</startdate><enddate>20240611</enddate><creator>Mizuno, Dai</creator><creator>Kawahara, Masahiro</creator><creator>Konoha-Mizuno, Keiko</creator><creator>Hama, Ryoji</creator><creator>Ogawara, Terumasa</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-4301-829X</orcidid><orcidid>https://orcid.org/0000-0002-3334-4235</orcidid></search><sort><creationdate>20240611</creationdate><title>The Role of Zinc in the Development of Vascular Dementia and Parkinson's Disease and the Potential of Carnosine as Their Therapeutic Agent</title><author>Mizuno, Dai ; Kawahara, Masahiro ; Konoha-Mizuno, Keiko ; Hama, Ryoji ; Ogawara, Terumasa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-a0374a00057950b60ef3d85cfd431705d209d8e7a2c225f8e1c7e0a7b36677fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Amino acids</topic><topic>Anguilla japonica</topic><topic>Apoptosis</topic><topic>Binswanger's disease</topic><topic>Carnosine</topic><topic>Cell death</topic><topic>Cytotoxicity</topic><topic>Dementia</topic><topic>Dementia disorders</topic><topic>Diet therapy</topic><topic>Disease</topic><topic>Diseases</topic><topic>Dopamine</topic><topic>endoplasmic reticulum stress</topic><topic>Enzymes</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Genes</topic><topic>Health aspects</topic><topic>Homeostasis</topic><topic>Hypothalamus</topic><topic>Ischemia</topic><topic>Japan</topic><topic>Kinases</topic><topic>Molecular modelling</topic><topic>Movement disorders</topic><topic>Neurodegenerative diseases</topic><topic>Neurotoxicity</topic><topic>Older people</topic><topic>Oxidative stress</topic><topic>Parkinson's disease</topic><topic>Pathogenesis</topic><topic>Physiological aspects</topic><topic>Proteins</topic><topic>Review</topic><topic>Sexually transmitted diseases</topic><topic>STD</topic><topic>synapse</topic><topic>Synaptogenesis</topic><topic>Therapeutic applications</topic><topic>Transcription factors</topic><topic>Vascular dementia</topic><topic>Zinc</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mizuno, Dai</creatorcontrib><creatorcontrib>Kawahara, Masahiro</creatorcontrib><creatorcontrib>Konoha-Mizuno, Keiko</creatorcontrib><creatorcontrib>Hama, Ryoji</creatorcontrib><creatorcontrib>Ogawara, Terumasa</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Biomedicines</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mizuno, Dai</au><au>Kawahara, Masahiro</au><au>Konoha-Mizuno, Keiko</au><au>Hama, Ryoji</au><au>Ogawara, Terumasa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Role of Zinc in the Development of Vascular Dementia and Parkinson's Disease and the Potential of Carnosine as Their Therapeutic Agent</atitle><jtitle>Biomedicines</jtitle><addtitle>Biomedicines</addtitle><date>2024-06-11</date><risdate>2024</risdate><volume>12</volume><issue>6</issue><spage>1296</spage><pages>1296-</pages><issn>2227-9059</issn><eissn>2227-9059</eissn><abstract>Synaptic zinc ions (Zn
) play an important role in the development of vascular dementia (VD) and Parkinson's disease (PD). In this article, we reviewed the current comprehension of the Zn
-induced neurotoxicity that leads to the pathogenesis of these neuronal diseases. Zn
-induced neurotoxicity was investigated by using immortalised hypothalamic neurons (GT1-7 cells). This cell line is useful for the development of a rapid and convenient screening system for investigating Zn
-induced neurotoxicity. GT1-7 cells were also used to search for substances that prevent Zn
-induced neurotoxicity. Among the tested substances was a protective substance in the extract of Japanese eel (
), and we determined its structure to be like carnosine (β-alanylhistidine). Carnosine may be a therapeutic drug for VD and PD. Furthermore, we reviewed the molecular mechanisms that involve the role of carnosine as an endogenous protector and its protective effect against Zn
-induced cytotoxicity and discussed the prospects for the future therapeutic applications of this dipeptide for neurodegenerative diseases and dementia.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>38927502</pmid><doi>10.3390/biomedicines12061296</doi><orcidid>https://orcid.org/0000-0002-4301-829X</orcidid><orcidid>https://orcid.org/0000-0002-3334-4235</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Biomedicines, 2024-06, Vol.12 (6), p.1296 |
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| recordid | cdi_doaj_primary_oai_doaj_org_article_d163b6d24cc540c4b22fce7a65e78ce6 |
| source | Publicly Available Content Database; PubMed Central |
| subjects | Amino acids Anguilla japonica Apoptosis Binswanger's disease Carnosine Cell death Cytotoxicity Dementia Dementia disorders Diet therapy Disease Diseases Dopamine endoplasmic reticulum stress Enzymes Ethylenediaminetetraacetic acid Genes Health aspects Homeostasis Hypothalamus Ischemia Japan Kinases Molecular modelling Movement disorders Neurodegenerative diseases Neurotoxicity Older people Oxidative stress Parkinson's disease Pathogenesis Physiological aspects Proteins Review Sexually transmitted diseases STD synapse Synaptogenesis Therapeutic applications Transcription factors Vascular dementia Zinc |
| title | The Role of Zinc in the Development of Vascular Dementia and Parkinson's Disease and the Potential of Carnosine as Their Therapeutic Agent |
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