Diurnal variation of NMDA receptor expression in the rat cerebral cortex is associated with traumatic brain injury damage

Data from our laboratory suggest that recovery from a traumatic brain injury depends on the time of day at which it occurred. In this study, we examined whether traumatic brain injury -induced damage is related to circadian variation in N-methyl-D-aspartate receptor expression in rat cortex. We conf...

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Bibliographic Details
Published in:BMC research notes 2018-02, Vol.11 (1), p.150-150, Article 150
Main Authors: Estrada-Rojo, Francisco, Morales-Gomez, Julio, Coballase-Urrutia, Elvia, Martinez-Vargas, Marina, Navarro, Luz
Format: Article
Language:English
Subjects:
Analysis
Animals
Apoptosis
Brain
Brain damage
Brain Injuries, Traumatic - metabolism
Brain Injuries, Traumatic - physiopathology
Cerebral cortex
Chemical properties
Circadian rhythm
Circadian Rhythm - physiology
Circadian rhythms
Cortex (motor)
Disease Models, Animal
Diurnal variations
Excitotoxicity
Fractures
Gene expression
Glutamate receptor
Glutamic acid receptors
Glutamic acid receptors (ionotropic)
Injuries
Ischemia
Laboratories
Male
Methyl aspartate
Motor Cortex - injuries
Motor Cortex - metabolism
Motor Cortex - physiopathology
N-Methyl-D-aspartic acid receptors
Neuroprotection
Rats
Rats, Wistar
Receptors, N-Methyl-D-Aspartate - metabolism
Research Note
Statistical significance
Time Factors
Traumatic brain injury
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Summary:Data from our laboratory suggest that recovery from a traumatic brain injury depends on the time of day at which it occurred. In this study, we examined whether traumatic brain injury -induced damage is related to circadian variation in N-methyl-D-aspartate receptor expression in rat cortex. We confirmed that traumatic brain injury recovery depended on the time of day at which the damage occurred. We also found that motor cortex N-methyl-D-aspartate receptor subunit NR1 expression exhibited diurnal variation in both control and traumatic brain injury-subjected rats. However, this rhythm is more pronounced in traumatic brain injury-subjected rats, with minimum expression in those injured during nighttime hours. These findings suggest that traumatic brain injury occurrence times should be considered in future clinical studies and when designing neuroprotective strategies for patients.
ISSN:1756-0500
1756-0500
DOI:10.1186/s13104-018-3258-0