Comprehensive Analysis of the Relationship between m6A Methylation Patterns and Immune Microenvironment in Lung Adenocarcinoma

m6A RNA methylation modification plays an important role in the occurrence and progression of lung cancer and regulates tumor immunity. Current studies mostly focus on the differential expression of some specific m6A effectors and infiltrating immune cell. m6A methylation modification is the result...

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Published in:Zhongguo fei ai za zhi 2022-05, Vol.25 (5), p.311-322
Main Authors: Ke, Ji, Cui, Jian, Yang, Xingguo, Du, Xin, Ma, Bobo, Yu, Lei
Format: Article
Language:Chinese
Subjects:
Acids
Biomarkers
Breast cancer
Correlation analysis
Cytotoxicity
Esophagus
Gene expression
Genomes
immune microenvironment
lrpprc
lung adenocarcinoma
Lung cancer
m6a modification
Metastasis
Mutation
Regression analysis
Stem cells
Survival analysis
Thoracic surgery
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Summary:m6A RNA methylation modification plays an important role in the occurrence and progression of lung cancer and regulates tumor immunity. Current studies mostly focus on the differential expression of some specific m6A effectors and infiltrating immune cell. m6A methylation modification is the result of mutual adjustment and balance between effectors, and changes in the expression of one or two effectors are far from enough to reflect the panorama of m6A methylation. The role of m6A in the immune microenvironment of lung adenocarcinoma (LUAD) is still poorly understood. The aim of this study is to investigate the effect of different m6A modification patterns in immune microenvironment of LUAD. LUAD data was obtained from The Cancer Genome Atlas (TCGA), University of California Santa Cruz Xena (UCSC Xena) and Gene Expression Omnibus (GEO) databases. Gene mutation, differential expression and survival analysis were performed for 24 m6A effectors. The m6A modification pattern was constructed by unsupervised cluste
ISSN:1009-3419
1999-6187
DOI:10.3779/j.issn.1009-3419.2022.103.02