Consciousness transitions during epilepsy seizures through the lens of integrated information theory

Consciousness is one of the most complex aspects of human experience. Studying the mechanisms involved in the transitions among different levels of consciousness remains as one of the greatest challenges in neuroscience. In this study we use a measure of integrated information (Φ AR ) to evaluate dy...

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Bibliographic Details
Published in:Scientific reports 2024-03, Vol.14 (1), p.5355-5355, Article 5355
Main Authors: Baglivo, F. H., Campora, N., Mininni, C. J., Kochen, S., Lew, S.
Format: Article
Language:English
Subjects:
631/378/1689
631/378/3920
Animals
Consciousness
Convulsions & seizures
EEG
Electrodes
Electroencephalography
Epilepsy
Fainting
Humanities and Social Sciences
Humans
Information Theory
Integrated information
Lens, Crystalline
Magnetic resonance imaging
multidisciplinary
Patients
Science
Science (multidisciplinary)
Seizures
Signal processing
Unionidae
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Summary:Consciousness is one of the most complex aspects of human experience. Studying the mechanisms involved in the transitions among different levels of consciousness remains as one of the greatest challenges in neuroscience. In this study we use a measure of integrated information (Φ AR ) to evaluate dynamic changes during consciousness transitions. We applied the measure to intracranial electroencephalography (SEEG) recordings collected from 6 patients that suffer from refractory epilepsy, taking into account inter-ictal, pre-ictal and ictal periods. We analyzed the dynamical evolution of Φ AR in groups of electrode contacts outside the epileptogenic region and compared it with the Consciousness Seizure Scale (CCS). We show that changes on Φ AR are significantly correlated with changes in the reported states of consciousness.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-56045-x