Associations between sarcopenia and circulating branched-chain amino acids: a cross-sectional study over 100,000 participants

Emerging evidence suggests that alterations in BCAA metabolism may contribute to the pathogenesis of sarcopenia. However, the relationship between branched-chain amino acids (BCAAs) and sarcopenia is incompletely understood, and existing literature presents conflicting results. In this study, we con...

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Published in:BMC geriatrics 2024-06, Vol.24 (1), p.541-12, Article 541
Main Authors: Liu, HuiMin, Zhang, Qiang, Hao, QianMeng, Li, QingSheng, Yang, LingFei, Yang, Xuan, Wang, KaiXin, Teng, JunFang, Gong, Zhe, Jia, YanJie
Format: Article
Language:English
Subjects:
Adult
Aged
Amino acids
Amino Acids, Branched-Chain - blood
Biobanks
Branched chain amino acids
Branched-chain amino acid
Cross-Sectional Studies
Exercise
Female
Gender
Hand grip strength
Health aspects
Humans
Isoleucine
Laboratories
Leucine
Male
Mediation analysis
Metabolism
Metabolites
Middle Aged
Muscle mass
Muscle strength
Muscle Strength - physiology
Muscle, Skeletal - metabolism
Older people
Prevention
Proteins
Regression analysis
Research ethics
Risk factors
Sarcopenia
Sarcopenia - blood
Sarcopenia - epidemiology
United Kingdom - epidemiology
Valine
Variables
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container_title BMC geriatrics
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creator Liu, HuiMin
Zhang, Qiang
Hao, QianMeng
Li, QingSheng
Yang, LingFei
Yang, Xuan
Wang, KaiXin
Teng, JunFang
Gong, Zhe
Jia, YanJie
description Emerging evidence suggests that alterations in BCAA metabolism may contribute to the pathogenesis of sarcopenia. However, the relationship between branched-chain amino acids (BCAAs) and sarcopenia is incompletely understood, and existing literature presents conflicting results. In this study, we conducted a community-based study involving > 100,000 United Kingdom adults to comprehensively explore the association between BCAAs and sarcopenia, and assess the potential role of muscle mass in mediating the relationship between BCAAs and muscle strength. Multivariable linear regression analysis examined the relationship between circulating BCAAs and muscle mass/strength. Logistic regression analysis assessed the impact of circulating BCAAs and quartiles of BCAAs on sarcopenia risk. Subgroup analyses explored the variations in associations across age, and gender. Mediation analysis investigated the potential mediating effect of muscle mass on the BCAA-muscle strength relationship. Among 108,017 participants (mean age: 56.40 ± 8.09 years; 46.23% men), positive associations were observed between total BCAA, isoleucine, leucine, valine, and muscle mass (beta, 0.56-2.53; p 
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However, the relationship between branched-chain amino acids (BCAAs) and sarcopenia is incompletely understood, and existing literature presents conflicting results. In this study, we conducted a community-based study involving &gt; 100,000 United Kingdom adults to comprehensively explore the association between BCAAs and sarcopenia, and assess the potential role of muscle mass in mediating the relationship between BCAAs and muscle strength. Multivariable linear regression analysis examined the relationship between circulating BCAAs and muscle mass/strength. Logistic regression analysis assessed the impact of circulating BCAAs and quartiles of BCAAs on sarcopenia risk. Subgroup analyses explored the variations in associations across age, and gender. Mediation analysis investigated the potential mediating effect of muscle mass on the BCAA-muscle strength relationship. Among 108,017 participants (mean age: 56.40 ± 8.09 years; 46.23% men), positive associations were observed between total BCAA, isoleucine, leucine, valine, and muscle mass (beta, 0.56-2.53; p &lt; 0.05) and between total BCAA, leucine, valine, and muscle strength (beta, 0.91-3.44; p &lt; 0.05). Logistic regression analysis revealed that increased circulating valine was associated with a 47% reduced sarcopenia risk (odds ratio = 0.53; 95% confidence interval = 0.3-0.94; p = 0.029). Subgroup analyses demonstrated strong associations between circulating BCAAs and muscle mass/strength in men and individuals aged ≥ 60 years. Mediation analysis suggested that muscle mass completely mediated the relationship between total BCAA, and valine levels and muscle strength, partially mediated the relationship between leucine levels and muscle strength, obscuring the true effect of isoleucine on muscle strength. This study suggested the potential benefits of BCAAs in preserving muscle mass/strength and highlighted muscle mass might be mediator of BCAA-muscle strength association. 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The Author(s).</rights><rights>COPYRIGHT 2024 BioMed Central Ltd.</rights><rights>2024. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c445t-58c12ff02352b908c96f945265ccef1c3da1146819659210ccde8d240226480d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11193178/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/3079182376?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25732,27903,27904,36991,36992,38495,43874,44569,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38907227$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, HuiMin</creatorcontrib><creatorcontrib>Zhang, Qiang</creatorcontrib><creatorcontrib>Hao, QianMeng</creatorcontrib><creatorcontrib>Li, QingSheng</creatorcontrib><creatorcontrib>Yang, LingFei</creatorcontrib><creatorcontrib>Yang, Xuan</creatorcontrib><creatorcontrib>Wang, KaiXin</creatorcontrib><creatorcontrib>Teng, JunFang</creatorcontrib><creatorcontrib>Gong, Zhe</creatorcontrib><creatorcontrib>Jia, YanJie</creatorcontrib><title>Associations between sarcopenia and circulating branched-chain amino acids: a cross-sectional study over 100,000 participants</title><title>BMC geriatrics</title><addtitle>BMC Geriatr</addtitle><description>Emerging evidence suggests that alterations in BCAA metabolism may contribute to the pathogenesis of sarcopenia. However, the relationship between branched-chain amino acids (BCAAs) and sarcopenia is incompletely understood, and existing literature presents conflicting results. In this study, we conducted a community-based study involving &gt; 100,000 United Kingdom adults to comprehensively explore the association between BCAAs and sarcopenia, and assess the potential role of muscle mass in mediating the relationship between BCAAs and muscle strength. Multivariable linear regression analysis examined the relationship between circulating BCAAs and muscle mass/strength. Logistic regression analysis assessed the impact of circulating BCAAs and quartiles of BCAAs on sarcopenia risk. Subgroup analyses explored the variations in associations across age, and gender. Mediation analysis investigated the potential mediating effect of muscle mass on the BCAA-muscle strength relationship. 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However, the relationship between branched-chain amino acids (BCAAs) and sarcopenia is incompletely understood, and existing literature presents conflicting results. In this study, we conducted a community-based study involving &gt; 100,000 United Kingdom adults to comprehensively explore the association between BCAAs and sarcopenia, and assess the potential role of muscle mass in mediating the relationship between BCAAs and muscle strength. Multivariable linear regression analysis examined the relationship between circulating BCAAs and muscle mass/strength. Logistic regression analysis assessed the impact of circulating BCAAs and quartiles of BCAAs on sarcopenia risk. Subgroup analyses explored the variations in associations across age, and gender. Mediation analysis investigated the potential mediating effect of muscle mass on the BCAA-muscle strength relationship. 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subjects Adult
Aged
Amino acids
Amino Acids, Branched-Chain - blood
Biobanks
Branched chain amino acids
Branched-chain amino acid
Cross-Sectional Studies
Exercise
Female
Gender
Hand grip strength
Health aspects
Humans
Isoleucine
Laboratories
Leucine
Male
Mediation analysis
Metabolism
Metabolites
Middle Aged
Muscle mass
Muscle strength
Muscle Strength - physiology
Muscle, Skeletal - metabolism
Older people
Prevention
Proteins
Regression analysis
Research ethics
Risk factors
Sarcopenia
Sarcopenia - blood
Sarcopenia - epidemiology
United Kingdom - epidemiology
Valine
Variables
title Associations between sarcopenia and circulating branched-chain amino acids: a cross-sectional study over 100,000 participants
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