Paget's disease of bone: an osteoimmunological disorder?

• Published in: Drug design, development and therapy development and therapy, 2015-01, Vol.9 (default), p.4695-4707
• Main Authors: Numan, Mohamed S, Amiable, Nathalie, Brown, Jacques P, Michou, Laëtitia
• Format: Article
• Language: English
• Subjects: Animals; Arthritis; Biocompatibility; Biomarkers; Biomarkers - blood; Bone and Bones - immunology; Bone and Bones - metabolism; Bone and Bones - pathology; Bone growth; Bone marrow; Bone Remodeling - drug effects; Bone resorption; Bones; Cascades; Cellular signal transduction; Crosstalk; Cytokines; Cytokines - blood; Cytokines - immunology; Cytotoxicity; Development and progression; Disorders; Genetic aspects; Granulocytes; Health aspects; Humans; Immune response; Immune system; Immunologic Factors - therapeutic use; Immunology; Inflammation; Inflammation Mediators - blood; Inflammation Mediators - immunology; Interferon; Interleukin 1; Interleukin 17; Interleukin 6; Ligands; Measles; Measles virus; Medical treatment; Molecular Targeted Therapy; Nucleocapsids; Osteitis deformans; Osteitis Deformans - blood; Osteitis Deformans - drug therapy; Osteitis Deformans - immunology; Osteitis Deformans - pathology; Osteogenesis; Osteoporosis; Osteoprotegerin; Periodontitis; Pharmacy; Prognosis; Properties; Psoriasis; Review; Rheumatoid arthritis; Rheumatology; Signal Transduction; Signaling; Stem cells; TRANCE protein; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Viruses; γ-Interferon
• ISSN: 1177-8881; 1177-8881
• DOI: 10.2147/DDDT.S88845

Osteoimmunology represents a large area of research resulting from the cross talk between bone and immune systems. Many cytokines and signaling cascades are involved in the field of osteoimmunology, originating from various cell types. The RANK/receptor activator of nuclear factor Kappa-B ligand (RANKL)/osteoprotegerin (OPG) signaling has a pivotal role in osteoimmunology, in addition to proinflammatory cytokines such as tumor necrosis factor-α, interleukin (IL)-1, IL-6, and IL-17. Clinically, osteoimmunological disorders, such as rheumatoid arthritis, osteoporosis, and periodontitis, should be classified according to their pattern of osteoimmunological serum biomarkers. Paget's disease of bone is a common metabolic bone disorder, resulting from an excessively increased bone resorption coupled with aberrant bone formation. With the exception of the cellular responses to measles virus nucleocapsid protein and the interferon-gamma signature, the exact role of the immune system in Paget's disease of bone is not well understood. The cytokine profiles, such as the increased levels of IL-6 and the interferon-gamma signature observed in this disease, are also very similar to those observed in other osteoimmunological disorders. As a potential osteoimmunological disorder, the treatment of Paget's disease of bone may also benefit from progress made in targeted therapies, in particular for receptor activator of nuclear factor Kappa-B ligand and IL-6 signaling inhibition.