Reactive Hyperemia-Triggered Wrist Pulse Analysis for Early Monitoring of Young Men with High Atherosclerotic Risk

The high prevalence of cardiovascular disease in young adults has raised significant concern regarding the early identification of risk factors to allow for timely intervention. This study aimed to identify young males at risk of atherosclerosis using a noninvasive instrument and an initial applicat...

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Bibliographic Details
Published in:Diagnostics (Basel) 2021-10, Vol.11 (10), p.1918
Main Authors: Chen, Jian-Jung, Wu, Hsien-Tsai, Haryadi, Bagus
Format: Article
Language:English
Subjects:
Atherosclerosis
Cardiovascular disease
cardiovascular disease (CVD)
Cardiovascular system
Cholesterol
Diabetes
dilation index (DI)
endothelial dysfunction (ED)
Health care
heart rate variability (HRV)
High density lipoprotein
Hospitals
Lifestyles
Lipoproteins
Metabolism
Obesity
Physiology
reactive hyperemia
Risk factors
Smoking
wrist pressure pulse (WPP)
Young adults
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Summary:The high prevalence of cardiovascular disease in young adults has raised significant concern regarding the early identification of risk factors to allow for timely intervention. This study aimed to identify young males at risk of atherosclerosis using a noninvasive instrument and an initial application percussion entropy analysis of the wrist pressure pulse (WPP). In total, 49 young males aged 18 to 28, without any known history of vascular disease, were recruited. Blood samples were obtained whereby a TC/HDL cutoff value of 4 was used to divide the young men into low-risk (Group 1, TC/HDL < 4, N = 32) and high-risk (Group 2, TC/HDL ≥ 4, N = 17) groups regarding atherosclerosis. The reactive hyperemia-triggered WPPs were measured using a modified air-pressure-sensing system (MAPSS). The dilation index (DI) of the endothelial function and percussion entropy index (PEI) of the heart rate variability (HRV) assessments, calculated using pragmatic signal-processing techniques, were compared between the two groups. The nonparametric Mann–Whitney U test showed that the DI and PEI of the two groups showed statistical differences (both p < 0.05). Not only could the MAPSS assess endothelial function and HRV in young males, but the results also showed that waist circumference and PEI may serve as indicators for the early identification of young males at risk of atherosclerosis.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics11101918