Activity-dependent dendrite patterning in the postnatal barrel cortex

For neural circuit construction in the brain, coarse neuronal connections are assembled prenatally following genetic programs, being reorganized postnatally by activity-dependent mechanisms to implement area-specific computational functions. Activity-dependent dendrite patterning is a critical compo...

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Bibliographic Details
Published in:Frontiers in neural circuits 2024-05, Vol.18, p.1409993-1409993
Main Authors: Nakagawa, Naoki, Iwasato, Takuji
Format: Article
Language:English
Subjects:
activity-dependent circuit formation
Animals
Asymmetry
barrel cortex
Computational neuroscience
Cortex (barrel)
dendrite refinement
Dendrites
Dendrites - physiology
Golgi apparatus
Humans
in vivo imaging
Kinases
Morphology
Neonates
Neural networks
Neuroimaging
Neurons
Pattern formation
postnatal brain development
Somatosensory cortex
Somatosensory Cortex - cytology
Somatosensory Cortex - growth & development
Somatosensory Cortex - physiology
Thalamus
Vibrissae - physiology
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Summary:For neural circuit construction in the brain, coarse neuronal connections are assembled prenatally following genetic programs, being reorganized postnatally by activity-dependent mechanisms to implement area-specific computational functions. Activity-dependent dendrite patterning is a critical component of neural circuit reorganization, whereby individual neurons rearrange and optimize their presynaptic partners. In the rodent primary somatosensory cortex (barrel cortex), driven by thalamocortical inputs, layer 4 (L4) excitatory neurons extensively remodel their basal dendrites at neonatal stages to ensure specific responses of barrels to the corresponding individual whiskers. This feature of barrel cortex L4 neurons makes them an excellent model, significantly contributing to unveiling the activity-dependent nature of dendrite patterning and circuit reorganization. In this review, we summarize recent advances in our understanding of the activity-dependent mechanisms underlying dendrite patterning. Our focus lays on the mechanisms revealed by time-lapse imaging, and the role of activity-dependent Golgi apparatus polarity regulation in dendrite patterning. We also discuss the type of neuronal activity that could contribute to dendrite patterning and hence connectivity.
ISSN:1662-5110
1662-5110
DOI:10.3389/fncir.2024.1409993