Multi-omics analysis and the remedial effects of Swertiamarin on hepatic injuries caused by CCl4

Hepatic diseases pose a significant threat to community health, impacting the quality of life and longevity of millions worldwide. Despite revolutionary advancements in treatment, liver diseases remain a pressing issue, necessitating the development of more effective therapeutic approaches. Here, we...

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Bibliographic Details
Published in:Ecotoxicology and environmental safety 2024-09, Vol.282, p.116734, Article 116734
Main Authors: Li, Linzhen, Xiao, Shengjia, Dai, Xiangjie, Tang, Zhiyi, Wang, Yutong, Ali, Munwar, Ataya, Farid Shokry, Sahar, Irna, Iqbal, Mujahid, Wu, Yi, Li, Kun
Format: Article
Language:English
Subjects:
CCl4
Liver damage
Metabonomics
Mice
Microbiome
Swertimarin
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Summary:Hepatic diseases pose a significant threat to community health, impacting the quality of life and longevity of millions worldwide. Despite revolutionary advancements in treatment, liver diseases remain a pressing issue, necessitating the development of more effective therapeutic approaches. Here, we conducted a comprehensive multi-omics analysis to investigate the underlying mechanism of Swertiamarin in alleviating hepatic injuries induced by CCl4 in mice. We divided 100 Kunming mice into five groups: RC (control), RM (CCl4), RD (15 mg/Kg Swertiamarin), RZ (30 mg/Kg Swertiamarin), and RG (60 mg/Kg Swertiamarin). Animals in groups RD, RZ, and RG received daily Swertiamarin via gavage, while those in groups RM, RD, RZ, and RG were treated with CCl4 solution intraperitoneally every four days, nine times in total. Our findings revealed that mice in the RM group exhibited slightly lower average weights compared to other groups, along with significantly higher liver weight (p
ISSN:0147-6513
1090-2414
1090-2414
DOI:10.1016/j.ecoenv.2024.116734