Anti-Obesity Potential of Sargassum horneri and Ulva australis Extracts: Study In Vitro and In Vivo

Current research highlights the use of natural products or phytochemicals as drugs and functional additives to treat obesity with few side effects. Sargassum horneri (SH) and Ulva australis (UA) are marine waste resources on Jeju Island, Republic of Korea. In this study, we analyzed their antioxidan...

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Bibliographic Details
Published in:Applied sciences 2023-08, Vol.13 (15), p.8951
Main Authors: Lee, Young-Hyeon, Kim, Hye-Ran, Yeo, Min-Ho, Kim, Sung Chun, Hyun, Ho-Bong, Ham, Young-Min, Jung, Yong-Hwan, Kim, Hye-Sook, Chang, Kyung-Soo
Format: Article
Language:English
Subjects:
Adipocytes
antioxidant
Antioxidants
Body fat
Body mass index
Ethanol
extract
Flavonoids
hyperlipidemia
Natural products
Obesity
Overweight
Phenols
Proteins
Reference materials
seaweed
Transcription factors
Womens health
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Summary:Current research highlights the use of natural products or phytochemicals as drugs and functional additives to treat obesity with few side effects. Sargassum horneri (SH) and Ulva australis (UA) are marine waste resources on Jeju Island, Republic of Korea. In this study, we analyzed their antioxidant and anti-obesity efficacies to confirm their potential as functional additives. We prepared SH and UA extracts using 80% ethanol and observed that free radical scavenging activity and total phenol content were high in SH extracts, and total flavonoid content was elevated in UA extracts. Additionally, 3T3-L1 cells were treated with SH and UA extracts, and the ability of the extracts to inhibit adipocyte differentiation was examined using Oil Red O staining and analysis of neutral fat content. We confirmed that the mRNA expression of the C/EBPα, PPARγ, and SREBP1c genes that act on adipocyte differentiation, and of FAS, a fatty acid synthase, was suppressed. Experiments in a mouse model of obesity showed that 12-week administration of a high-fat diet with 1% extract added to drinking water resulted in lower weight gain compared to the high-fat diet alone. These results suggest that SH and UA extracts have antioxidant properties and are effective in obesity prevention. Therefore, the two marine waste resources are potential functional additive candidates for preventing obesity.
ISSN:2076-3417
2076-3417
DOI:10.3390/app13158951