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Role of Different Subpopulations of CD8 + T Cells during HIV Exposure and Infection
During HIV infection, specific responses exhibited by CD8 T cells are crucial to establish an early, effective, and sustained viral control, preventing severe immune alterations and organ dysfunction. Several CD8 T cells subsets have been identified, exhibiting differences in terms of activation, fu...
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Published in: | Frontiers in immunology 2017-08, Vol.8, p.936-936 |
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Main Authors: | , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | During HIV infection, specific responses exhibited by CD8
T cells are crucial to establish an early, effective, and sustained viral control, preventing severe immune alterations and organ dysfunction. Several CD8
T cells subsets have been identified, exhibiting differences in terms of activation, functional profile, and ability to limit HIV replication. Some of the most important CD8
T cells subsets associated with viral control, production of potent antiviral molecules, and strong polyfunctional responses include Th1-like cytokine pattern and Tc17 cells. In addition, the expression of specific activation markers has been also associated with a more effective response of CD8
T cells, as evidenced in HLA-DR
CD38
cells. CD8
T cells in both, peripheral blood and gut mucosa, are particularly important in individuals with a resistant phenotype, including HIV-exposed seronegative individuals (HESNs), long-term non-progressors (LTNPs) and HIV-controllers. Although the role of CD8
T cells has been extensively explored in the context of an established HIV-1 infection, the presence of HIV-specific cells with effector abilities and a defined functional profile in HESNs, remain poorly understood. Here, we reviewed studies carried out on different subpopulations of CD8
T cells in relation with natural resistance to HIV infection and progression. |
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ISSN: | 1664-3224 1664-3224 |
DOI: | 10.3389/fimmu.2017.00936 |