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Clinical Parameters and Outcomes of Biliary Atresia in Children: A Single Centre Study
ABSTRACT Objective: To assess the clinical and laboratory parameters, interventions and their outcomes in children presenting with biliary atresia at a tertiary care hospital. Study Design: Prospective longitudinal study. Place and Duration of study: Pediatric Gastroenterology and Hepatology Departm...
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Published in: | Pakistan Armed Forces medical journal 2024-08, Vol.74 (4), p.956 |
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description | ABSTRACT Objective: To assess the clinical and laboratory parameters, interventions and their outcomes in children presenting with biliary atresia at a tertiary care hospital. Study Design: Prospective longitudinal study. Place and Duration of study: Pediatric Gastroenterology and Hepatology Department of Combined Military Hospital, Rawalpindi Pakistan, from Feb 2021 to Jan 2022. Methodology: Patients diagnosed with extrahepatic biliary atresia on the basis of liver histopathology and intra operative cholangiogram were enrolled consecutively during this period. The clinical parameters, liver function tests, radiological investigations and histopathology findings were recorded and correlated. The impact of Kasai procedure on outcome and prognosis of biliary atresia patients was noted along with an interval analysis at 1 year of age. Results: Forty patients were studied including 26 males and 14 females. Thirty (75%) patients underwent Kasai at a median age of 3.14±1.2 months with a success rate of 66.6% (p-value0.05). A statistically significant relation was established between one-year outcomes of patients undergoing Kasai Hepatic Portoenterostomy and without Kasai Hepatic Portoenterostomy (p-value 0.01). A significant difference in survival of patients undergoing Kasai Hepatic Portoenterostomy and those without Kasai Hepatic Portoenterostomy (p< 0.001) was observed. Conclusion: Intervention in the form of Kasai Hepatic Portoenterostomy significantly contributes towards an improved outcome in patients with Biliary Atresia. |
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Study Design: Prospective longitudinal study. Place and Duration of study: Pediatric Gastroenterology and Hepatology Department of Combined Military Hospital, Rawalpindi Pakistan, from Feb 2021 to Jan 2022. Methodology: Patients diagnosed with extrahepatic biliary atresia on the basis of liver histopathology and intra operative cholangiogram were enrolled consecutively during this period. The clinical parameters, liver function tests, radiological investigations and histopathology findings were recorded and correlated. The impact of Kasai procedure on outcome and prognosis of biliary atresia patients was noted along with an interval analysis at 1 year of age. Results: Forty patients were studied including 26 males and 14 females. Thirty (75%) patients underwent Kasai at a median age of 3.14±1.2 months with a success rate of 66.6% (p-value<0.01). No significant correlation was established between age at Kasai Hepatic Portoenterostomy and success of Kasai Hepatic Portoenterostomy (p-value>0.05). A statistically significant relation was established between one-year outcomes of patients undergoing Kasai Hepatic Portoenterostomy and without Kasai Hepatic Portoenterostomy (p-value 0.01). A significant difference in survival of patients undergoing Kasai Hepatic Portoenterostomy and those without Kasai Hepatic Portoenterostomy (p< 0.001) was observed. Conclusion: Intervention in the form of Kasai Hepatic Portoenterostomy significantly contributes towards an improved outcome in patients with Biliary Atresia.</description><identifier>ISSN: 0030-9648</identifier><identifier>EISSN: 2411-8842</identifier><identifier>DOI: 10.51253/pafmj.v74i4.9280</identifier><language>eng</language><publisher>Rawalpindi: Knowledge Bylanes</publisher><subject>Abdomen ; Age ; Bile ducts ; Biliary atresia ; Biliary atresia, Gamma glutamyl transferase, Hepatic portoenterostomy, Jaundice, Kasai ; Biopsy ; Cholangitis ; Cytomegalovirus ; Diseases ; Females ; Gender ; Histopathology ; Hypertension ; Infants (Newborn) ; Liver ; Liver diseases ; Medical prognosis ; Pediatrics ; Phosphatase ; Proteins ; Survival analysis ; Transplantation of organs, tissues, etc ; Transplants & implants</subject><ispartof>Pakistan Armed Forces medical journal, 2024-08, Vol.74 (4), p.956</ispartof><rights>COPYRIGHT 2024 Knowledge Bylanes</rights><rights>(c)2024 Pakistan Armed Forces Medical Journal</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/3101102694/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/3101102694?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,25753,27924,27925,37012,44590,74998</link.rule.ids></links><search><creatorcontrib>Nawaz, Raazia</creatorcontrib><creatorcontrib>Farooq Ikram</creatorcontrib><creatorcontrib>Bilal</creatorcontrib><creatorcontrib>Saba Idrees</creatorcontrib><creatorcontrib>Shamraiz, Ifnan</creatorcontrib><creatorcontrib>Tabassum, Samina</creatorcontrib><title>Clinical Parameters and Outcomes of Biliary Atresia in Children: A Single Centre Study</title><title>Pakistan Armed Forces medical journal</title><description>ABSTRACT Objective: To assess the clinical and laboratory parameters, interventions and their outcomes in children presenting with biliary atresia at a tertiary care hospital. Study Design: Prospective longitudinal study. Place and Duration of study: Pediatric Gastroenterology and Hepatology Department of Combined Military Hospital, Rawalpindi Pakistan, from Feb 2021 to Jan 2022. Methodology: Patients diagnosed with extrahepatic biliary atresia on the basis of liver histopathology and intra operative cholangiogram were enrolled consecutively during this period. The clinical parameters, liver function tests, radiological investigations and histopathology findings were recorded and correlated. The impact of Kasai procedure on outcome and prognosis of biliary atresia patients was noted along with an interval analysis at 1 year of age. Results: Forty patients were studied including 26 males and 14 females. Thirty (75%) patients underwent Kasai at a median age of 3.14±1.2 months with a success rate of 66.6% (p-value<0.01). No significant correlation was established between age at Kasai Hepatic Portoenterostomy and success of Kasai Hepatic Portoenterostomy (p-value>0.05). A statistically significant relation was established between one-year outcomes of patients undergoing Kasai Hepatic Portoenterostomy and without Kasai Hepatic Portoenterostomy (p-value 0.01). A significant difference in survival of patients undergoing Kasai Hepatic Portoenterostomy and those without Kasai Hepatic Portoenterostomy (p< 0.001) was observed. Conclusion: Intervention in the form of Kasai Hepatic Portoenterostomy significantly contributes towards an improved outcome in patients with Biliary Atresia.</description><subject>Abdomen</subject><subject>Age</subject><subject>Bile ducts</subject><subject>Biliary atresia</subject><subject>Biliary atresia, Gamma glutamyl transferase, Hepatic portoenterostomy, Jaundice, Kasai</subject><subject>Biopsy</subject><subject>Cholangitis</subject><subject>Cytomegalovirus</subject><subject>Diseases</subject><subject>Females</subject><subject>Gender</subject><subject>Histopathology</subject><subject>Hypertension</subject><subject>Infants (Newborn)</subject><subject>Liver</subject><subject>Liver diseases</subject><subject>Medical prognosis</subject><subject>Pediatrics</subject><subject>Phosphatase</subject><subject>Proteins</subject><subject>Survival analysis</subject><subject>Transplantation of organs, tissues, etc</subject><subject>Transplants & implants</subject><issn>0030-9648</issn><issn>2411-8842</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptjk9r3DAQxUVpoUuSD9CboGdv9d9Sb1uTpoFACml7NWNpvNViS1vZG8i3r9IE0kNmDgPvvfnxCPnA2VZzoeWnI4zzYXvfqqi2Tlj2hmyE4ryxVom3ZMOYZI0zyr4nF8tyYHW0FIrpDfnVTTFFDxP9DgVmXLEsFFKgt6fV5xkXmkf6JU4RygPdrQWXCDQm2v2OUyiYPtMdvYtpPyHtMFWf3q2n8HBO3o0wLXjxfM_Iz6-XP7pvzc3t1XW3u2kCN1w1g0GlULfGQTBBB6vd6Jm04LwWQQycWz24AazyrUGsIh9CO4xCtEJY4-QZuX7ihgyH_ljiXHv2GWL_T8hl30NZo5-wD9zb4JUbreYKgwXJ3KAd81LwIPCR9fGJdSz5zwmXtT_kU0m1fi8545wJ49RLag8VGtOY1wJ-jovvd5a1ynBpWU1tX0nVDThHnxOOser_PfwFLfGIDg</recordid><startdate>20240831</startdate><enddate>20240831</enddate><creator>Nawaz, Raazia</creator><creator>Farooq Ikram</creator><creator>Bilal</creator><creator>Saba Idrees</creator><creator>Shamraiz, Ifnan</creator><creator>Tabassum, Samina</creator><general>Knowledge Bylanes</general><general>AsiaNet Pakistan (Pvt) Ltd</general><general>Army Medical College Rawalpindi</general><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>DOA</scope></search><sort><creationdate>20240831</creationdate><title>Clinical Parameters and Outcomes of Biliary Atresia in Children: A Single Centre Study</title><author>Nawaz, Raazia ; Farooq Ikram ; Bilal ; Saba Idrees ; Shamraiz, Ifnan ; Tabassum, Samina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-d1614-b6e44e5769ad6d5d859fc038a9c52d2b1185b9ba84c76eec521bd7bf227228693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Abdomen</topic><topic>Age</topic><topic>Bile ducts</topic><topic>Biliary atresia</topic><topic>Biliary atresia, Gamma glutamyl transferase, Hepatic portoenterostomy, Jaundice, Kasai</topic><topic>Biopsy</topic><topic>Cholangitis</topic><topic>Cytomegalovirus</topic><topic>Diseases</topic><topic>Females</topic><topic>Gender</topic><topic>Histopathology</topic><topic>Hypertension</topic><topic>Infants (Newborn)</topic><topic>Liver</topic><topic>Liver diseases</topic><topic>Medical prognosis</topic><topic>Pediatrics</topic><topic>Phosphatase</topic><topic>Proteins</topic><topic>Survival analysis</topic><topic>Transplantation of organs, tissues, etc</topic><topic>Transplants & implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nawaz, Raazia</creatorcontrib><creatorcontrib>Farooq Ikram</creatorcontrib><creatorcontrib>Bilal</creatorcontrib><creatorcontrib>Saba Idrees</creatorcontrib><creatorcontrib>Shamraiz, Ifnan</creatorcontrib><creatorcontrib>Tabassum, Samina</creatorcontrib><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Directory of Open Access Journals</collection><jtitle>Pakistan Armed Forces medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nawaz, Raazia</au><au>Farooq Ikram</au><au>Bilal</au><au>Saba Idrees</au><au>Shamraiz, Ifnan</au><au>Tabassum, Samina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Parameters and Outcomes of Biliary Atresia in Children: A Single Centre Study</atitle><jtitle>Pakistan Armed Forces medical journal</jtitle><date>2024-08-31</date><risdate>2024</risdate><volume>74</volume><issue>4</issue><spage>956</spage><pages>956-</pages><issn>0030-9648</issn><eissn>2411-8842</eissn><abstract>ABSTRACT Objective: To assess the clinical and laboratory parameters, interventions and their outcomes in children presenting with biliary atresia at a tertiary care hospital. Study Design: Prospective longitudinal study. Place and Duration of study: Pediatric Gastroenterology and Hepatology Department of Combined Military Hospital, Rawalpindi Pakistan, from Feb 2021 to Jan 2022. Methodology: Patients diagnosed with extrahepatic biliary atresia on the basis of liver histopathology and intra operative cholangiogram were enrolled consecutively during this period. The clinical parameters, liver function tests, radiological investigations and histopathology findings were recorded and correlated. The impact of Kasai procedure on outcome and prognosis of biliary atresia patients was noted along with an interval analysis at 1 year of age. Results: Forty patients were studied including 26 males and 14 females. Thirty (75%) patients underwent Kasai at a median age of 3.14±1.2 months with a success rate of 66.6% (p-value<0.01). No significant correlation was established between age at Kasai Hepatic Portoenterostomy and success of Kasai Hepatic Portoenterostomy (p-value>0.05). A statistically significant relation was established between one-year outcomes of patients undergoing Kasai Hepatic Portoenterostomy and without Kasai Hepatic Portoenterostomy (p-value 0.01). A significant difference in survival of patients undergoing Kasai Hepatic Portoenterostomy and those without Kasai Hepatic Portoenterostomy (p< 0.001) was observed. Conclusion: Intervention in the form of Kasai Hepatic Portoenterostomy significantly contributes towards an improved outcome in patients with Biliary Atresia.</abstract><cop>Rawalpindi</cop><pub>Knowledge Bylanes</pub><doi>10.51253/pafmj.v74i4.9280</doi><oa>free_for_read</oa></addata></record> |
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subjects | Abdomen Age Bile ducts Biliary atresia Biliary atresia, Gamma glutamyl transferase, Hepatic portoenterostomy, Jaundice, Kasai Biopsy Cholangitis Cytomegalovirus Diseases Females Gender Histopathology Hypertension Infants (Newborn) Liver Liver diseases Medical prognosis Pediatrics Phosphatase Proteins Survival analysis Transplantation of organs, tissues, etc Transplants & implants |
title | Clinical Parameters and Outcomes of Biliary Atresia in Children: A Single Centre Study |
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