Glassy-like Metal Oxide Particles Embedded on Micrometer Thicker Alginate Films as Promising Wound Healing Nanomaterials

Micrometer-thicker, biologically responsive nanocomposite films were prepared starting from alginate-metal alkoxide colloidal solution followed by sol-gel chemistry and solvent removal through evaporation-induced assembly. The disclosed approach is straightforward and highly versatile, allowing the...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-05, Vol.23 (10), p.5585
Main Authors: Kędzierska, Marta, Hammi, Nisrine, Kolodziejczyk-Czepas, Joanna, Katir, Nadia, Bryszewska, Maria, Milowska, Katarzyna, El Kadib, Abdelkrim
Format: Article
Language:English
Subjects:
alginate
Alginates
Alginic acid
Aqueous solutions
Biocompatibility
Biological activity
Carbohydrates
Comparative studies
Entrapment
Evaporation
flexible films
hemolytic activity
Keratinocytes
metal oxide clusters
Metal oxides
Methemoglobin
Nanocomposites
Nanomaterials
Nanoparticles
Nanotechnology
Polymerization
Prothrombin
prothrombin and thrombine time
Sol-gel processes
Solubilization
Tissue engineering
Titanium
Titanium dioxide
Wound healing
Zinc oxides
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Summary:Micrometer-thicker, biologically responsive nanocomposite films were prepared starting from alginate-metal alkoxide colloidal solution followed by sol-gel chemistry and solvent removal through evaporation-induced assembly. The disclosed approach is straightforward and highly versatile, allowing the entrapment and growth of a set of glassy-like metal oxide within the network of alginate and their shaping as crake-free transparent and flexible films. Immersing these films in aqueous medium triggers alginate solubilization, and affords water-soluble metal oxides wrapped in a biocompatible carbohydrate framework. Biological activity of the nano-composites films was also studied including their hemolytic activity, methemoglobin, prothrombin, and thrombine time. The effect of the films on fibroblasts and keratinocytes of human skin was also investigated with a special emphasis on the role played by the incorporated metal oxide. This comparative study sheds light on the crucial biological response of the ceramic phase embedded inside of the films, with titanium dioxide being the most promising for wound healing purposes.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23105585