Synthesis and Anthelmintic Activity of New Thiosemicarbazide Derivatives-A Preliminary Study

Parasitic infections caused by different species of intestinal helminths still poses a threat to public health. There is a need to search for new, effective anthelmintic drugs. A series of novel thiosemicarbazides were synthesized and evaluated for their in vitro anthelmintic activity. The prelimina...

Full description

Saved in:
Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2020-06, Vol.25 (12), p.2770
Main Authors: Dziduch, Katarzyna, Kołodziej, Przemysław, Paneth, Agata, Bogucka-Kocka, Anna, Wujec, Monika
Format: Article
Language:English
Subjects:
Animals
anthelmintic activity
Anthelmintic agents
Antinematodal Agents - chemical synthesis
Antinematodal Agents - chemistry
Antinematodal Agents - pharmacology
Antiparasitic agents
Cancer
Carbonyl compounds
Carbonyls
Ethanol
Health risks
Infections
intestinal helminths
Intestine
Molecular Structure
Mortality
Nematodes
Parasites
Parasitic diseases
Public health
Rhabditis sp
Rhabditoidea - growth & development
Semicarbazides - chemical synthesis
Semicarbazides - chemistry
Semicarbazides - pharmacology
thiosemicarbazide
Thiosemicarbazides
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Parasitic infections caused by different species of intestinal helminths still poses a threat to public health. There is a need to search for new, effective anthelmintic drugs. A series of novel thiosemicarbazides were synthesized and evaluated for their in vitro anthelmintic activity. The preliminary results showed that the most of synthesized compounds were very active. 4-Phenyl-1-[(1-methyl-4-nitroimidazol-2-yl)carbonyl]thiosemicarbazide and 4-(3-chlorophenyl)-1-[(1-methyl-4-nitroimidazol-2-yl)carbonyl]thiosemicarbazide showed a 100% mortality of nematodes and a high anthelmintic activity in both tested concentrations.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules25122770