Use of the Serum Wisteria floribunda Agglutinin-Positive Mac2 Binding Protein as a Marker of Gastroesophageal Varices and Liver-Related Events in Chronic Hepatitis C Patients

A test to narrow down patients who require esophagogastroduodenoscopy (EGD) with a high probability of having gastroesophageal varices (GEV) and a high-risk of liver-related events is an unmet need. The measurement of serum fibrosis markers and EGD was performed in 166 consecutive chronic hepatitis...

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Published in:Diagnostics (Basel) 2020-03, Vol.10 (3), p.173
Main Authors: Hayashi, Tsuguru, Tamaki, Nobuharu, Kurosaki, Masayuki, Wang, Wan, Okada, Mao, Higuchi, Mayu, Takaura, Kenta, Takada, Hitomi, Yasui, Yutaka, Tsuchiya, Kaoru, Nakanishi, Hiroyuki, Itakura, Jun, Harada, Masaru, Izumi, Namiki
Format: Article
Language:English
Subjects:
Blood platelets
Blood tests
chronic hepatitis c
Endoscopy
gastroesophageal varices
Hepatitis
Hepatitis C
Hypertension
Liver
Patients
wfa+–m2bp
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Summary:A test to narrow down patients who require esophagogastroduodenoscopy (EGD) with a high probability of having gastroesophageal varices (GEV) and a high-risk of liver-related events is an unmet need. The measurement of serum fibrosis markers and EGD was performed in 166 consecutive chronic hepatitis C patients. The correlation between the grades of GEV and fibrosis markers and the subsequent occurrence of liver-related and fibrosis markers were examined. agglutinin-positive human Mac-2 binding protein (WFA -M2BP) levels increased according to the grade of GEV (3.4 (0.2-18.6) for no GEV, 7.9 (1.8-20.0) for small GEV, and 11.4 (4.0-20.0) for large GEV; < 0.001). The diagnostic accuracy of the WFA -M2BP was superior compared to other serum fibrosis markers, and WFA -M2BP was an independent predictor of GEV in the multivariate analysis. Furthermore, the cumulative incidence of liver-related events at one year was 2.3% in patients with WFA -M2BP levels ≤ 7.0 and 37.5% in patients with WFA -M2BP levels > 7.0 ( < 0.001). WFA -M2BP > 7.0 was a significant predictive factor for liver-related events (Hazard ratio 6.7, = 0.004) independent of Child-Pughclass. WFA -M2BP could be used to estimate the presence and grade of GEV and is linked to liver-related events in chronic hepatitis C patients.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics10030173