Effects of Allogeneic Mesenchymal Stem Cell Transplantation in Dogs with Inflammatory Bowel Disease Treated with and without Corticosteroids

• Published in: Animals (Basel) 2021-07, Vol.11 (7), p.2061
• Main Authors: Cristóbal, José Ignacio, Duque, Francisco Javier, Usón-Casaús, Jesús María, Ruiz, Patricia, Nieto, Esther López, Pérez-Merino, Eva María
• Format: Article
• Language: English
• Subjects: Abdomen; Albumin; Albumins; Animals; Cell therapy; chronic enteropathy; Clinical trials; Corticoids; Corticosteroids; Dosage; Drug dosages; Evaluation; Feasibility; Health services; Hematology; Immunosuppressive agents; Inflammatory bowel disease; Inflammatory bowel diseases; Intestine; Laboratories; Medical treatment; Mesenchymal stem cells; Patients; Physiology; Prednisone; Signs and symptoms; Stem cell transplantation; Stem cells; Steroid hormones; Steroids; Transplantation; Ultrasonic imaging; Veterinary medicine; Vitamin B12
• ISSN: 2076-2615; 2076-2615
• DOI: 10.3390/ani11072061

Mesenchymal stem cells have proven to be a promising alternative to conventional steroids to treat canine inflammatory bowel disease (IBD). However, their administration requires a washout period of immunosuppressive drugs that can lead to an exacerbation of the symptoms. Therefore, the feasibility and effects of the combined application of stem cells and prednisone in IBD-dogs without adequate response to corticosteroids was evaluated for the first time in this study over a long- term follow up. Two groups of dogs with IBD, one without treatment and another with prednisone treatment, received a single infusion of stem cells. The clinical indices, albumin and cobalamin were determined prior to the infusion and after one, three, six and 12 months. In both groups, all parameters significantly improved at each time point. In parallel, the steroid dosage was gradually reduced until it was suppressed in all patients a year after the cell therapy. Therefore, cell therapy can significantly and safely improve the disease condition in dogs with IBD receiving or not receiving prednisone. Furthermore, the steroid dosage can be significantly reduced or cancelled after the stem cell infusion. Their beneficial effects are stable over time and are long lasting.