Indirect estimation of reference intervals for thyroid parameters using advia centaur XP analyzer

The aim of this study was to determine the reference intervals (RIs) for thyroid stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3) and FT3/FT4 ratio using indirect methods. We analyzed 1256 results TSH, FT4 and FT3 collected from a laboratory information system between 201...

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Bibliographic Details
Published in:Journal of medical biochemistry 2022-04, Vol.41 (2), p.238-245
Main Authors: Mirjanić-Azarić, Bosa, Milinković, Neda, Bogavac-Stanojević, Natasa, Avram, Sanja, Stojaković-Jelisavac, Tanja, Stojanović, Darja
Format: Article
Language:English
Subjects:
indirect methods
Original Paper
reference intervals
thyroid parameters
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Summary:The aim of this study was to determine the reference intervals (RIs) for thyroid stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3) and FT3/FT4 ratio using indirect methods. We analyzed 1256 results TSH, FT4 and FT3 collected from a laboratory information system between 2017 and 2021. All measurements were performed on a Siemens ADVIA Centaur XP analyzer using the chemiluminescent immunoassay. We calculated the values of the 2.5th and 97.5th percentiles as recommended by the IFCC (CLSI C28-A3). The RIs derived for TSH, FT4, FT3 and FT3/FT4 ratio were 0.34-4.10 mIU/L, 11.3-20.6 pmol/L, 3.5-6.32 pmol/L and 0.21-0.47, respectively. We found a significant difference between calculated RIs for the TSH and FT4 and those recommended by the manufacturer. Also, FT3 values were significantly higher in the group younger than 30 years relative to the fourth decade (5.26 vs. 5.02, p=0.005), the fifth decade (5.26 vs. 4.94, p=0.001), the sixth decade (5.26 vs. 4.87, p
ISSN:1452-8258
1452-8266
DOI:10.5937/jomb0-33543