Preliminary screening of the possible protective effect of Moroccan propolis against chromium-induced nephrotoxicity in animal model

Hexavalent chromium (Cr (VI)) compounds have been shown to induce nephrotoxicity associated with oxidative stress in humans and animals. The aim of the present study was to investigate the nephroprotective effect of bee propolis, as highly antioxidant natural product, using an animal model. First of...

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Bibliographic Details
Published in:Veterinary World 2020-07, Vol.13 (7), p.1327-1333
Main Authors: El-Guendouz, Soukaina, Zizi, Soumia, Elamine, Youssef, Lyoussi, Badiaa
Format: Article
Language:English
Subjects:
Animal models
antioxidant
Antioxidants
Antioxidants (Nutrients)
Chromium
Creatinine
Flavonoids
Isoflavones
Natural products
Oxidative stress
Phenols
Polyphenols
Potassium
Potassium dichromate
Propolis
renal damage
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Summary:Hexavalent chromium (Cr (VI)) compounds have been shown to induce nephrotoxicity associated with oxidative stress in humans and animals. The aim of the present study was to investigate the nephroprotective effect of bee propolis, as highly antioxidant natural product, using an animal model. First of all, total phenol and flavonoid contents of propolis sample were estimated . Afterward, to study the protective effect of propolis on renal damages caused by an injection of a single dose of potassium dichromate (15 mg/kg b.wt), 24 male Wister rats were divided into test and control groups. Propolis treatment was performed by oral gavage of 100 mg/kg b.wt/day, while the control groups received water instead. The 24 h urine was collected and blood samples were withdrawn before and after each treatment for further analysis. Propolis revealed to be rich in polyphenols and flavonoids. Chromate provoked a nephrotoxic effect expressed by a drastic decrease in glomerular filtration assessed by creatinine clearance. However, the administration of propolis attenuated the renal damages induced by the chromate. This attenuation can be seen by the increase of creatinine clearance when comparing propolis treated group to the non-treated group. Propolis showed a protective potential against chromate-induced nephrotoxicity through the amelioration of chromate's toxic effects. It might be concluded that propolis could be effective as chemoprotectant in the management of potassium dichromate-induced nephrotoxicity.
ISSN:0972-8988
2231-0916
DOI:10.14202/vetworld.2020.1327-1333