Transfer of photothermal nanoparticles using stem cell derived small extracellular vesicles for in vivo treatment of primary and multinodular tumours

The main current challenges in oncology are (1) avoiding systemic side effects in therapy, and (2) developing alternative treatment strategies for metastatic tumours. Nanomedicine was assumed to provide answers to these issues, but delivering enough therapeutic nanoparticles (NPs) to tumours still r...

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Bibliographic Details
Published in:Journal of extracellular vesicles 2022-03, Vol.11 (3), p.e12193-n/a
Main Authors: Sancho‐Albero, María, Encinas‐Giménez, Miguel, Sebastián, Victor, Pérez, Estela, Luján, Lluís, Santamaría, Jesús, Martin‐Duque, Pilar
Format: Article
Language:English
Subjects:
Cancer therapies
Cell culture
Cell interactions
Cell Line, Tumor
Extracellular Vesicles
Fever
gold nanoparticles
Hyperthermia
Hyperthermia, Induced
Membranes
Metastases
Microscopy
multinodular cancer and NIR laser
Nanoparticles
Nanoparticles - therapeutic use
Nanotechnology
optical hyperthermia
Proteins
Remission
Side effects
Solid tumors
Stem Cells
Tumors
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Summary:The main current challenges in oncology are (1) avoiding systemic side effects in therapy, and (2) developing alternative treatment strategies for metastatic tumours. Nanomedicine was assumed to provide answers to these issues, but delivering enough therapeutic nanoparticles (NPs) to tumours still remains a huge challenge in nanomaterials‐based treatments. Extracellular vesicles (EVs) play a key role in cell communication processes and can be combined with nanomaterials to improve their targeting capabilities. In this work, we leverage the ability of EVs derived from stem cells to reach tumour areas successfully, being used as delivery vehicles for nanoparticles acting as hyperthermia agents. Once small extracellular vesicles (sEVs) loaded with NIR‐sensitive hollow gold NPs reached primary subcutaneous solid tumours, they were irradiated with a NIR laser and almost complete tumour remission was obtained. More interestingly, those sEV vehicles were also able to reach multinodular areas similar to those on advanced metastatic phases, eradicating most tumour growth regions in multiple cancerous nodules located in the pancreas region.
ISSN:2001-3078
2001-3078
DOI:10.1002/jev2.12193