A Review in Research Progress Concerning m6A Methylation and Immunoregulation

Over 100 types of cellular RNA modifications have been identified in both coding and a variety of non-coding RNAs. N6-methyladenosine (m6A) is the most prevalent and abundant post-transcriptional RNA modification on eukaryote mRNA, and its biological functions are mediated by special binding protein...

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Bibliographic Details
Published in:Frontiers in immunology 2019-04, Vol.10, p.922-922
Main Authors: Zhang, Caiyan, Fu, Jinrong, Zhou, Yufeng
Format: Article
Language:English
Subjects:
binding proteins
cellular functions
Immunology
immunoregulation
mechanisms
N6-methyladenosine
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Summary:Over 100 types of cellular RNA modifications have been identified in both coding and a variety of non-coding RNAs. N6-methyladenosine (m6A) is the most prevalent and abundant post-transcriptional RNA modification on eukaryote mRNA, and its biological functions are mediated by special binding proteins (i.e., methyltransferases, demethylases, and effectors) that recognize this modification. The presence of m6A on transcripts contributes to diverse fundamental cellular functions, such as pre-mRNA splicing, nuclear transport, stability, translation, and microRNA biogenesis, implying an association with numerous human diseases. This review principally summarizes recent progress in the study of m6A methylation mechanisms and relevant roles they play in immunoregulation.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2019.00922