Loading…

Specific patterns of neural activity in the hippocampus after massed or distributed spatial training

Training with long inter-session intervals, termed distributed training , has long been known to be superior to training with short intervals, termed massed training . In the present study we compared c-Fos expression after massed and distributed training protocols in the Morris water maze to outlin...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2023-08, Vol.13 (1), p.13357-13357, Article 13357
Main Authors: Centofante, Eleonora, Fralleoni, Luca, Lupascu, Carmen A., Migliore, Michele, Rinaldi, Arianna, Mele, Andrea
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c518t-a938b6360df91d003e7477fe526293381a4fb4b3baef71373d339499a31567373
cites cdi_FETCH-LOGICAL-c518t-a938b6360df91d003e7477fe526293381a4fb4b3baef71373d339499a31567373
container_end_page 13357
container_issue 1
container_start_page 13357
container_title Scientific reports
container_volume 13
creator Centofante, Eleonora
Fralleoni, Luca
Lupascu, Carmen A.
Migliore, Michele
Rinaldi, Arianna
Mele, Andrea
description Training with long inter-session intervals, termed distributed training , has long been known to be superior to training with short intervals, termed massed training . In the present study we compared c-Fos expression after massed and distributed training protocols in the Morris water maze to outline possible differences in the learning-induced pattern of neural activation in the dorsal CA1 in the two training conditions. The results demonstrate that training and time lags between learning opportunities had an impact on the pattern of neuronal activity in the dorsal CA1. Mice trained with the distributed protocol showed sustained neuronal activity in the postero-distal component of the dorsal CA1. In parallel, in trained mice we found more active cells that tended to constitute spatially restricted clusters, whose degree increased with the increase in the time lags between learning trials. Moreover, activated cell assemblies demonstrated increased stability in their spatial organization after distributed as compared to massed training or control condition. Finally, using a machine learning algorithm we found that differences in the number of c-Fos positive cells and their location in the dorsal CA1 could be predictive of the training protocol used. These results suggest that the topographic organization and the spatial location of learning activated cell assemblies might be critical to promote the increased stability of the memory trace induced by distributed training.
doi_str_mv 10.1038/s41598-023-39882-0
format article
fullrecord <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_d24175ca61b1439d988043a0105b59f3</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_d24175ca61b1439d988043a0105b59f3</doaj_id><sourcerecordid>2851548816</sourcerecordid><originalsourceid>FETCH-LOGICAL-c518t-a938b6360df91d003e7477fe526293381a4fb4b3baef71373d339499a31567373</originalsourceid><addsrcrecordid>eNp9kk1vFSEUhidGY5vaP-CKxI2bUeDADKyMafxo0sSFuiYMH_dyMxdGYJr035d2mta6kA0ceN8nnJO3694S_IFgEB8LI1yKHlPoQQpBe_yiO6WY8Z4CpS__Op9056UccFucSkbk6-4ERi7G9nba2Z-LM8EHgxZdq8uxoORRdGvWM9KmhutQb1CIqO4d2odlSUYfl7Ug7ZsaHXUpzqKUkQ2l5jCttZWlsULz16xDDHH3pnvl9Vzc-cN-1v3--uXXxff-6se3y4vPV73hRNReSxDTAAO2XhKLMbiRjaN3nA5UAgiimZ_YBJN2fiQwggWQTEoNhA9jq8-6y41rkz6oJYejzjcq6aDuL1LeKZ1rMLNTljIycqMHMhEG0rYRYgYaE8wnLj001qeNtazT0VnjYutmfgZ9_hLDXu3StSKNQzkjjfD-gZDTn9WVqo6hGDfPOrq0FkVFawzwwGmTvvtHekhrjm1WdyrCmRBkaCq6qUxOpWTnH39DsLoLhdpCoVoo1H0oFG4m2EyliePO5Sf0f1y3Pqa3tg</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2851548816</pqid></control><display><type>article</type><title>Specific patterns of neural activity in the hippocampus after massed or distributed spatial training</title><source>Publicly Available Content Database</source><source>Full-Text Journals in Chemistry (Open access)</source><source>PubMed Central</source><source>Springer Nature - nature.com Journals - Fully Open Access</source><creator>Centofante, Eleonora ; Fralleoni, Luca ; Lupascu, Carmen A. ; Migliore, Michele ; Rinaldi, Arianna ; Mele, Andrea</creator><creatorcontrib>Centofante, Eleonora ; Fralleoni, Luca ; Lupascu, Carmen A. ; Migliore, Michele ; Rinaldi, Arianna ; Mele, Andrea</creatorcontrib><description>Training with long inter-session intervals, termed distributed training , has long been known to be superior to training with short intervals, termed massed training . In the present study we compared c-Fos expression after massed and distributed training protocols in the Morris water maze to outline possible differences in the learning-induced pattern of neural activation in the dorsal CA1 in the two training conditions. The results demonstrate that training and time lags between learning opportunities had an impact on the pattern of neuronal activity in the dorsal CA1. Mice trained with the distributed protocol showed sustained neuronal activity in the postero-distal component of the dorsal CA1. In parallel, in trained mice we found more active cells that tended to constitute spatially restricted clusters, whose degree increased with the increase in the time lags between learning trials. Moreover, activated cell assemblies demonstrated increased stability in their spatial organization after distributed as compared to massed training or control condition. Finally, using a machine learning algorithm we found that differences in the number of c-Fos positive cells and their location in the dorsal CA1 could be predictive of the training protocol used. These results suggest that the topographic organization and the spatial location of learning activated cell assemblies might be critical to promote the increased stability of the memory trace induced by distributed training.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-023-39882-0</identifier><identifier>PMID: 37587232</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/378/116/2395 ; 631/378/1595 ; 631/378/1595/1554 ; c-Fos protein ; Humanities and Social Sciences ; Learning ; multidisciplinary ; Neurosciences ; Protocol ; Science ; Science (multidisciplinary)</subject><ispartof>Scientific reports, 2023-08, Vol.13 (1), p.13357-13357, Article 13357</ispartof><rights>The Author(s) 2023</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Springer Nature Limited 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c518t-a938b6360df91d003e7477fe526293381a4fb4b3baef71373d339499a31567373</citedby><cites>FETCH-LOGICAL-c518t-a938b6360df91d003e7477fe526293381a4fb4b3baef71373d339499a31567373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2851548816/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2851548816?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25752,27923,27924,37011,37012,44589,53790,53792,74897</link.rule.ids></links><search><creatorcontrib>Centofante, Eleonora</creatorcontrib><creatorcontrib>Fralleoni, Luca</creatorcontrib><creatorcontrib>Lupascu, Carmen A.</creatorcontrib><creatorcontrib>Migliore, Michele</creatorcontrib><creatorcontrib>Rinaldi, Arianna</creatorcontrib><creatorcontrib>Mele, Andrea</creatorcontrib><title>Specific patterns of neural activity in the hippocampus after massed or distributed spatial training</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><description>Training with long inter-session intervals, termed distributed training , has long been known to be superior to training with short intervals, termed massed training . In the present study we compared c-Fos expression after massed and distributed training protocols in the Morris water maze to outline possible differences in the learning-induced pattern of neural activation in the dorsal CA1 in the two training conditions. The results demonstrate that training and time lags between learning opportunities had an impact on the pattern of neuronal activity in the dorsal CA1. Mice trained with the distributed protocol showed sustained neuronal activity in the postero-distal component of the dorsal CA1. In parallel, in trained mice we found more active cells that tended to constitute spatially restricted clusters, whose degree increased with the increase in the time lags between learning trials. Moreover, activated cell assemblies demonstrated increased stability in their spatial organization after distributed as compared to massed training or control condition. Finally, using a machine learning algorithm we found that differences in the number of c-Fos positive cells and their location in the dorsal CA1 could be predictive of the training protocol used. These results suggest that the topographic organization and the spatial location of learning activated cell assemblies might be critical to promote the increased stability of the memory trace induced by distributed training.</description><subject>631/378/116/2395</subject><subject>631/378/1595</subject><subject>631/378/1595/1554</subject><subject>c-Fos protein</subject><subject>Humanities and Social Sciences</subject><subject>Learning</subject><subject>multidisciplinary</subject><subject>Neurosciences</subject><subject>Protocol</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp9kk1vFSEUhidGY5vaP-CKxI2bUeDADKyMafxo0sSFuiYMH_dyMxdGYJr035d2mta6kA0ceN8nnJO3694S_IFgEB8LI1yKHlPoQQpBe_yiO6WY8Z4CpS__Op9056UccFucSkbk6-4ERi7G9nba2Z-LM8EHgxZdq8uxoORRdGvWM9KmhutQb1CIqO4d2odlSUYfl7Ug7ZsaHXUpzqKUkQ2l5jCttZWlsULz16xDDHH3pnvl9Vzc-cN-1v3--uXXxff-6se3y4vPV73hRNReSxDTAAO2XhKLMbiRjaN3nA5UAgiimZ_YBJN2fiQwggWQTEoNhA9jq8-6y41rkz6oJYejzjcq6aDuL1LeKZ1rMLNTljIycqMHMhEG0rYRYgYaE8wnLj001qeNtazT0VnjYutmfgZ9_hLDXu3StSKNQzkjjfD-gZDTn9WVqo6hGDfPOrq0FkVFawzwwGmTvvtHekhrjm1WdyrCmRBkaCq6qUxOpWTnH39DsLoLhdpCoVoo1H0oFG4m2EyliePO5Sf0f1y3Pqa3tg</recordid><startdate>20230816</startdate><enddate>20230816</enddate><creator>Centofante, Eleonora</creator><creator>Fralleoni, Luca</creator><creator>Lupascu, Carmen A.</creator><creator>Migliore, Michele</creator><creator>Rinaldi, Arianna</creator><creator>Mele, Andrea</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><general>Nature Portfolio</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20230816</creationdate><title>Specific patterns of neural activity in the hippocampus after massed or distributed spatial training</title><author>Centofante, Eleonora ; Fralleoni, Luca ; Lupascu, Carmen A. ; Migliore, Michele ; Rinaldi, Arianna ; Mele, Andrea</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c518t-a938b6360df91d003e7477fe526293381a4fb4b3baef71373d339499a31567373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>631/378/116/2395</topic><topic>631/378/1595</topic><topic>631/378/1595/1554</topic><topic>c-Fos protein</topic><topic>Humanities and Social Sciences</topic><topic>Learning</topic><topic>multidisciplinary</topic><topic>Neurosciences</topic><topic>Protocol</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Centofante, Eleonora</creatorcontrib><creatorcontrib>Fralleoni, Luca</creatorcontrib><creatorcontrib>Lupascu, Carmen A.</creatorcontrib><creatorcontrib>Migliore, Michele</creatorcontrib><creatorcontrib>Rinaldi, Arianna</creatorcontrib><creatorcontrib>Mele, Andrea</creatorcontrib><collection>SpringerOpen</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Centofante, Eleonora</au><au>Fralleoni, Luca</au><au>Lupascu, Carmen A.</au><au>Migliore, Michele</au><au>Rinaldi, Arianna</au><au>Mele, Andrea</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Specific patterns of neural activity in the hippocampus after massed or distributed spatial training</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><date>2023-08-16</date><risdate>2023</risdate><volume>13</volume><issue>1</issue><spage>13357</spage><epage>13357</epage><pages>13357-13357</pages><artnum>13357</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Training with long inter-session intervals, termed distributed training , has long been known to be superior to training with short intervals, termed massed training . In the present study we compared c-Fos expression after massed and distributed training protocols in the Morris water maze to outline possible differences in the learning-induced pattern of neural activation in the dorsal CA1 in the two training conditions. The results demonstrate that training and time lags between learning opportunities had an impact on the pattern of neuronal activity in the dorsal CA1. Mice trained with the distributed protocol showed sustained neuronal activity in the postero-distal component of the dorsal CA1. In parallel, in trained mice we found more active cells that tended to constitute spatially restricted clusters, whose degree increased with the increase in the time lags between learning trials. Moreover, activated cell assemblies demonstrated increased stability in their spatial organization after distributed as compared to massed training or control condition. Finally, using a machine learning algorithm we found that differences in the number of c-Fos positive cells and their location in the dorsal CA1 could be predictive of the training protocol used. These results suggest that the topographic organization and the spatial location of learning activated cell assemblies might be critical to promote the increased stability of the memory trace induced by distributed training.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>37587232</pmid><doi>10.1038/s41598-023-39882-0</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2045-2322
ispartof Scientific reports, 2023-08, Vol.13 (1), p.13357-13357, Article 13357
issn 2045-2322
2045-2322
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_d24175ca61b1439d988043a0105b59f3
source Publicly Available Content Database; Full-Text Journals in Chemistry (Open access); PubMed Central; Springer Nature - nature.com Journals - Fully Open Access
subjects 631/378/116/2395
631/378/1595
631/378/1595/1554
c-Fos protein
Humanities and Social Sciences
Learning
multidisciplinary
Neurosciences
Protocol
Science
Science (multidisciplinary)
title Specific patterns of neural activity in the hippocampus after massed or distributed spatial training
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T23%3A05%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Specific%20patterns%20of%20neural%20activity%20in%20the%20hippocampus%20after%20massed%20or%20distributed%20spatial%20training&rft.jtitle=Scientific%20reports&rft.au=Centofante,%20Eleonora&rft.date=2023-08-16&rft.volume=13&rft.issue=1&rft.spage=13357&rft.epage=13357&rft.pages=13357-13357&rft.artnum=13357&rft.issn=2045-2322&rft.eissn=2045-2322&rft_id=info:doi/10.1038/s41598-023-39882-0&rft_dat=%3Cproquest_doaj_%3E2851548816%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c518t-a938b6360df91d003e7477fe526293381a4fb4b3baef71373d339499a31567373%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2851548816&rft_id=info:pmid/37587232&rfr_iscdi=true