Comparison of Th1 and Th2 responses in non-healing and healing patients with cutaneous leishmaniasis

Cutaneous leishmaniasis is an endemic disease in many regions of Iran, including the city of Mashhad. In recent years, some cases have not responded to Glucantime, the usual treatment for this disease. The cellular immune response caused by T-helper type 1 (Th1) cells has an important role in protec...

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Bibliographic Details
Published in:Reports of biochemistry and molecular biology 2013-04, Vol.1 (2), p.43-48
Main Authors: Shahi, Maryam, Mohajery, Masoud, Shamsian, Seyyed Ali Akbar, Nahrevanian, Hossein, Yazdanpanah, Seyyed Mohammad Javad
Format: Article
Language:English
Subjects:
Cutaneous leishmaniasis
Cytokines
Glucantime
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Summary:Cutaneous leishmaniasis is an endemic disease in many regions of Iran, including the city of Mashhad. In recent years, some cases have not responded to Glucantime, the usual treatment for this disease. The cellular immune response caused by T-helper type 1 (Th1) cells has an important role in protection against leishmaniasis, and activation of the T-helper type 2 (Th2) response causes progression of the disease. By analyzing these responses we hope to find a more effective treatment than that currently in use for leishmaniasis patients. The cellular immune responses in 60 cases of non-healing and healing cutaneous leishmaniasis, and individuals in a control group, were analyzed by measuring cytokines released by peripheral blood mononuclear cells (PBMCs) when stimulated with Leishmania major antigens by Enzyme Linked Immuno Sorbent Assay (ELISA). Subjects from the healing group secreted more interleukin-12 (IL-12) and interferon gamma (IFN-γ) (p
ISSN:2322-3480
2322-3480