Regioselective alkynylation followed by Suzuki coupling of 2,4-dichloroquinoline: synthesis of 2-alkynyl-4-arylquinolines

A two step synthesis of 2-alkynyl-4-arylquinolines has been accomplished via Pd/C-mediated regioselective C-2 alkynylation of 2,4-dichloroquinoline in water followed by Suzuki coupling at C-4 of the resulting 4-chloro derivative.

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Published in:Beilstein journal of organic chemistry 2009-07, Vol.5 (1), p.32-32
Main Authors: Reddy, Ellanki Amarender, Islam, Aminul, Mukkanti, K, Bandameedi, Venkanna, Bhowmik, Dipal Ranjan, Pal, Manojit
Format: Article
Language:English
Subjects:
2,4-dichloroquinoline
alkyne
boronic acid
catalysis
Chemistry
palladium
Preliminary Communication
water
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cited_by cdi_FETCH-LOGICAL-c440t-1c481a85e51058a18f0d624a0aa61559c5bcc6cc95be89b07a98db487f5c25c73
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description A two step synthesis of 2-alkynyl-4-arylquinolines has been accomplished via Pd/C-mediated regioselective C-2 alkynylation of 2,4-dichloroquinoline in water followed by Suzuki coupling at C-4 of the resulting 4-chloro derivative.
doi_str_mv 10.3762/bjoc.5.32
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subjects 2,4-dichloroquinoline
alkyne
boronic acid
catalysis
Chemistry
palladium
Preliminary Communication
water
title Regioselective alkynylation followed by Suzuki coupling of 2,4-dichloroquinoline: synthesis of 2-alkynyl-4-arylquinolines
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