The Diagnostic Performance of Chest-X-Ray and Erythrocyte Sedimentation Rate in Comparison with GeneXpert ® for Tuberculosis Case Notification Among Patients Living with Human Immunodeficiency Virus in a Resource-Limited Setting: A Cross-Sectional Study

For many years, chest-X-ray (CXR) has been used as a diagnostic tool to complement clinical diagnosis of bacteriologically negative tuberculosis (TB) cases. Increased erythrocyte sedimentation rate (ESR) was also used as laboratory surrogates to augment the diagnosis of bacteriological test negative...

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Bibliographic Details
Published in:Risk management and healthcare policy 2020-01, Vol.13, p.1639-1646
Main Author: Sorsa, Abebe
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Age
AIDS
Anemia
Blood
Calcification
Cross-sectional studies
cxr
Drug therapy
Erythrocytes
esr
Fever
genexpert
HIV
Hospitals
Human immunodeficiency virus
Laboratories
Medical diagnosis
Original Research
Pathology
Patients
plhiv
Tuberculosis
X-rays
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Summary:For many years, chest-X-ray (CXR) has been used as a diagnostic tool to complement clinical diagnosis of bacteriologically negative tuberculosis (TB) cases. Increased erythrocyte sedimentation rate (ESR) was also used as laboratory surrogates to augment the diagnosis of bacteriological test negative TB cases. The objective of this study was to evaluate the diagnostic performance of CXR and ESR in comparison with geneXpert for TB case notification among PLHIV in a resource-limited setting. An institution-based cross-sectional study was carried out from February 1, 2018-January 31, 2019. During regular HIV-clinic visits, PLHIVs were assessed for TB using the National and WHO screening tool, and those with positive results were further evaluated using ESR, CXR and sputum for AFB and GeneXpert . Patients were interviewed for demographic and clinical data using a standardized tool. Collected data were analyzed using SPSS 21. Frequency, percentage, cross tabulation and proportion were used to describe variables of importance. Logistic regression was used to assess factors affecting CXR and ESR findings. Kappa was used to assess reliability, and a -value
ISSN:1179-1594
1179-1594
DOI:10.2147/RMHP.S264447