Ligustrum japonicum Thunb. Fruits Exert Antiosteoporotic Properties in Bone Marrow-Derived Mesenchymal Stromal Cells via Regulation of Adipocyte and Osteoblast Differentiation

Ligustrum japonicum fruits have been used as a part of traditional medicinal practices and supplements in Korea and Japan. It has been reported to possess various bioactivities, but its antiosteoporotic potential and active substances have not been reported yet. The present study followed an ALP act...

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Bibliographic Details
Published in:Stem cells international 2021, Vol.2021, p.8851884-17
Main Authors: Oh, Jung Hwan, Karadeniz, Fatih, Lee, Jung Im, Seo, Youngwan, Kong, Chang-Suk
Format: Article
Language:English
Subjects:
Accumulation
Acids
Adipocytes
Adipogenesis
Biomarkers
Biomedical materials
Bone marrow
Cell culture
Cell growth
Diabetes
Differentiation
Fruit
Fruits
Gene expression
Ligustrum japonicum
Lipids
MAP kinase
Mesenchymal stem cells
Mesenchyme
Metabolism
Metabolites
Osteoblastogenesis
Osteoporosis
Salidroside
Scientific equipment and supplies industry
Signal transduction
Solvents
Stem cells
Stromal cells
Wnt protein
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Summary:Ligustrum japonicum fruits have been used as a part of traditional medicinal practices and supplements in Korea and Japan. It has been reported to possess various bioactivities, but its antiosteoporotic potential and active substances have not been reported yet. The present study followed an ALP activity and lipid accumulation-guided screening of L. japonicum fruits for antiosteoporotic compounds and isolated salidroside as an active compound. Antiosteoporotic effects of L. japonicum fruits and salidroside were examined in mesenchymal stromal cells by their ability to enhance osteoblast formation by increased ALP activity and osteogenic marker gene expression while suppressing adipogenesis by inhibition of lipid accumulation and adipocyte marker gene expressions. Results showed that salidroside was able to enhance osteoblast differentiation via Wnt/BMP signaling pathway overactivation and suppress the PPARĪ³-mediated adipocyte differentiation, both through the MAPK pathway. In conclusion, L. japonicum fruits were suggested to possess antiosteoporotic activities and to be a source of antiosteoporotic substances such as salidroside.
ISSN:1687-966X
1687-9678
1687-9678
DOI:10.1155/2021/8851884