Improving effect of Actinidia arguta leaf on hyperglycemia-induced cognitive dysfunction

• Published in: Journal of functional foods 2021-01, Vol.76, p.104315, Article 104315
• Main Authors: Yoo, Seul Ki, Kang, Jin Yong, Lee, Uk, Park, Seon Kyeong, Kim, Jong Min, Han, Hye Ju, Kim, Dae Ok, Heo, Ho Jin
• Format: Article
• Language: English
• Subjects: Actinidia argute leaf; Cognitive decline; Diabetes mellitus; Flavonoids; Oxidative stress
• ISSN: 1756-4646; 2214-9414
• DOI: 10.1016/j.jff.2020.104315

[Display omitted] •Actinidia arguta leaf extract ameliorated hyperglycemia caused by diabetes.•Actinidia arguta leaf extract suppressed brain damage caused by diabetes.•Flavonol glycosides are major compounds of Actinidia arguta leaf extract.•Actinidia argute leaf is valuable source for treating diabetic cognitive decline. This study was performed to investigate the effect of ethyl acetate fraction from Actinidia arguta leaf (EFAL) in improving cognitive decline caused by hyperglycemia-induced oxidative stress. EFAL suppressed hyperglycemia and improved glucose tolerance in streptozotocin (STZ)-induced diabetic mice. In behavioral tests, cognitive dysfunction was present in diabetic mice, whereas cognitive function was improved by EFAL treatment. All serum oxidative damage markers decreased in the EFAL groups. Brain tissue analysis showed that the oxidative stress marker malondialdehyde (MDA) decreased and the antioxidant enzyme superoxide dismutase (SOD) increased with EFAL treatment compared with diabetic mice. In addition, the reduction of neurotransmitters and mitochondrial dysfunction were suppressed by EFAL. Improvement of the insulin signaling pathway with the reduction of Tau phosphorylation and decrease in amyloid beta (Aβ) by increasing IDE expression in EFAL group was also observed. Finally, oxo-dihydroxy-octadecenoic acid (oxo-DHODE), rutin, and kaempferol-3-O-rutinoside were identified as the main compounds of EFAL.