Potential of Curcumin in the Management of Skin Diseases

Curcumin is a polyphenolic molecule derived from the rhizoma of L. This compound has been used for centuries due to its anti-inflammatory, antioxidant, and antimicrobial properties. These make it ideal for preventing and treating skin inflammation, premature skin ageing, psoriasis, and acne. Additio...

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Bibliographic Details
Published in:International journal of molecular sciences 2024-04, Vol.25 (7), p.3617
Main Authors: Kasprzak-Drozd, Kamila, Niziński, Przemysław, Hawrył, Anna, Gancarz, Marek, Hawrył, Dominika, Oliwa, Weronika, Pałka, Magdalena, Markowska, Julia, Oniszczuk, Anna
Format: Article
Language:English
Subjects:
Aging, Premature
Antifungal agents
B cells
Bioavailability
Collagen
curcumin
Curcumin - pharmacology
Curcumin - therapeutic use
Dermatitis
Development and progression
Drug delivery systems
Enzymes
Health aspects
Humans
Inflammation
Kinases
Large intestine
Metabolism
Metabolites
Psoriasis
Radiation
scleroderma
Skin
Skin diseases
Skin Diseases - drug therapy
skin infections
Topical medication
Tumor necrosis factor-TNF
wound healing
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Summary:Curcumin is a polyphenolic molecule derived from the rhizoma of L. This compound has been used for centuries due to its anti-inflammatory, antioxidant, and antimicrobial properties. These make it ideal for preventing and treating skin inflammation, premature skin ageing, psoriasis, and acne. Additionally, it exhibits antiviral, antimutagenic, and antifungal effects. Curcumin provides protection against skin damage caused by prolonged exposure to UVB radiation. It reduces wound healing times and improves collagen deposition. Moreover, it increases fibroblast and vascular density in wounds. This review summarizes the available information on the therapeutic effect of curcumin in treating skin diseases. The results suggest that curcumin may be an inexpensive, well-tolerated, and effective agent for treating skin diseases. However, larger clinical trials are needed to confirm these observations due to limitations in its in vivo use, such as low bioavailability after oral administration and metabolism.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25073617