3169 Complex movement disorder following hypoxic brain injury secondary to cocaine overdose

Case ReportIntoxication with cocaine has been associated with toxic leukoencephalopathy in addition to other metabolic and cardiac consequences. Cocaine addiction has been associated with altered iron metabolism and deposition in the brain.A 44 year old female was bought in to hospital following an...

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Bibliographic Details
Published in:BMJ neurology open 2024-08, Vol.6 (Suppl 1), p.A49-A49
Main Authors: Kline, Katharine, Gopinath, Sumana
Format: Article
Language:English
Subjects:
Cocaine
Hypoxia
Poster Abstracts
Traumatic brain injury
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Summary:Case ReportIntoxication with cocaine has been associated with toxic leukoencephalopathy in addition to other metabolic and cardiac consequences. Cocaine addiction has been associated with altered iron metabolism and deposition in the brain.A 44 year old female was bought in to hospital following an out of hospital cardiac arrest secondary to cocaine intoxication with return of spontaneous circulation following 90 minutes of good quality cardiopulmonary resuscitation. Neurological recovery was slow and complicated by several acute medical issues. Neurological responsiveness fluctuated after the first few days, suggesting possible seizures in the context of hypoxic brain injury, EEG consistent with encephalopathy. On day 10, asymmetrical movements with head turned to right, right arm extended and right hip and knee flexed. MRI brain day 11 was in keeping with hypoxic brain injury: extensive cortical high signal changes more prominent on right side, and hyperintensity in bilateral caudate + lentiform nuclei. Subsequent MRI brain has shown improvement. The movement disorders seen post hypoxic brain injury, and effect of cocaine toxicity on these will be discussed.
ISSN:2632-6140
DOI:10.1136/bmjno-2024-ANZAN.138