Deregulated Serotonin Pathway in Women with Morbid Obesity and NAFLD

Non-alcoholic fatty liver disease (NAFLD) extends from simple steatosis (SS) to non-alcoholic steatohepatitis (NASH). Peripheral serotonin (5-HT) has become as an important regulator of different metabolic pathways. 5-HT has been related to obesity and lipid accumulation in the liver. The objective...

Full description

Saved in:
Bibliographic Details
Published in:Life (Basel, Switzerland) Switzerland), 2020-10, Vol.10 (10), p.245
Main Authors: Binetti, Jessica, Bertran, Laia, Riesco, David, Aguilar, Carmen, Martínez, Salomé, Sabench, Fàtima, Porras, Jose Antonio, Camaron, Javier, Castillo, Daniel Del, Richart, Cristóbal, Auguet, Teresa
Format: Article
Language:English
Subjects:
bariatric surgery
Biopsy
Cardiovascular disease
Deregulation
Fatty liver
Gastrointestinal surgery
Glucose
Homeostasis
Hypocaloric diet
Inflammation
Insulin resistance
Lipids
Liver
Liver diseases
Metabolic disorders
Metabolic pathways
Metabolic syndrome
Metabolism
Metabolites
morbid obesity
mRNA
non-alcoholic fatty liver disease
Obesity
Pathogenesis
Serotonin
Serotonin receptors
Signal transduction
Steatosis
Womens health
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Non-alcoholic fatty liver disease (NAFLD) extends from simple steatosis (SS) to non-alcoholic steatohepatitis (NASH). Peripheral serotonin (5-HT) has become as an important regulator of different metabolic pathways. 5-HT has been related to obesity and lipid accumulation in the liver. The objective of this study was to assess the relationship between the 5-HT signaling pathway and the degree of NAFLD, as well as to investigate whether peripheral 5-HT levels are related to the hepatic and jejunal mRNA abundance of serotonin receptors (HTR) in a cohort of women with morbid obesity (MO) and NAFLD. ELISA was used to quantify the serum 5-HT from normal-weight subjects (n = 26) and patients with MO (n = 58). We used RTq-PCR analysis to evaluate the relative expression of HTR in women with MO with normal liver (n = 22), SS (n = 21), and NASH (n = 15). The 5-HT was diminished in women with MO under a hypocaloric diet, regardless of the presence of NAFLD. Additionally, we report a negative correlation of 5-HT levels with metabolic syndrome criteria, suggesting that serotonin may have a protective role in obesity. Additionally, the hepatic expression of HTR2A and HTR2B were decreased in women with MO and NAFLD, but no significant differences in the HTR jejunal expression according to the presence of NAFLD were found.
ISSN:2075-1729
2075-1729
DOI:10.3390/life10100245