Adult Intestinal Botulism: A Rare Presentation in an Immunocompromised Patient With Short Bowel Syndrome

The cholinergic heat-labile neurotoxin produced by Clostridium species is primarily responsible for the clinical manifestations of botulism. The classic phenotypic presentation of botulism consists of subacute descending flaccid paralysis with intact sensory function. Traditionally, it is classified...

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Bibliographic Details
Published in:Mayo Clinic proceedings. Innovations, quality & outcomes quality & outcomes, 2018-09, Vol.2 (3), p.291-296
Main Authors: Guru, Pramod K., Becker, Tara L., Stephens, Alana, Cannistraro, Rocco J., Eidelman, Benjamin H., Hata, D. Jane, Brumble, Lisa
Format: Article
Language:English
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Case Report
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Summary:The cholinergic heat-labile neurotoxin produced by Clostridium species is primarily responsible for the clinical manifestations of botulism. The classic phenotypic presentation of botulism consists of subacute descending flaccid paralysis with intact sensory function. Traditionally, it is classified into 3 main forms (foodborne, wound-related, and infantile) on the basis of primary site of toxin entry into the human nervous system. Toxemia is the common pathophysiology in all forms of botulism. Adult intestinal toxemia botulism is an extremely rare form of the disease with pathogenesis similar to that of infant-type botulism. Symptomatic adults usually have an anatomic abnormality in the gastrointestinal tract leading to changes in normal gut flora. The current case is an addition to the growing literature on this unusual clinical variant of botulism.
ISSN:2542-4548
2542-4548
DOI:10.1016/j.mayocpiqo.2018.06.005