Prevalence of Hypocortisolemia in Patients with Sepsis or Septic Shock (The HIS Study) Presenting to the Emergency Department

Cortisol response to stressors (hypothalamic-pituitary-adrenal axis, autonomic nervous system, and immune system) plays a vital role in maintaining stable metabolic homeostasis. This study was done to assess the prevalence of hypocortisolemia in patients presenting to ED with sepsis and/or septic sh...

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Bibliographic Details
Published in:Indian journal of endocrinology and metabolism 2023-11, Vol.27 (6), p.530-536
Main Authors: Pienyu, Peleneilhou, Hazra, Darpanarayan, Chandy, Gina M, Sharma, Parth, Jeeyavudeen, Mohammad S, Abhilash, Kundavaram P P
Format: Article
Language:English
Subjects:
ACTH
Analysis
Corticosteroids
cortisol levels
Emergency service
Hormones
Hospitals
hypocortisolemia
Infection
Lactates
Medical research
Medicine, Experimental
Sepsis
Septic shock
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Summary:Cortisol response to stressors (hypothalamic-pituitary-adrenal axis, autonomic nervous system, and immune system) plays a vital role in maintaining stable metabolic homeostasis. This study was done to assess the prevalence of hypocortisolemia in patients presenting to ED with sepsis and/or septic shock. This prospective observational study was done from July 2020 to April 2021. Serum cortisol levels were measured in patients with sepsis and septic shock, and their clinical and laboratory profile was categorized, coded, and analyzed. Ninety-eight patients were included, of which serum Cortisol
ISSN:2230-8210
2230-9500
2230-8210
2230-9500
DOI:10.4103/ijem.ijem_286_22